The Acute Effects of Blood Flow Restriction on Ankle Muscle Reaction Time and Proprioception in Healthy Individuals

NCT07307339 | Active Not Recruiting

• 1 other identifier: 2025-15/31
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

his randomized controlled crossover study aims to investigate the acute effects of lower limb blood flow restriction (BFR) on ankle joint proprioception, postural control, and muscle activation in healthy adults. Each participant will complete test sessions under BFR (60% individualized arterial occlusion pressure) and control (20 mmHg sham) conditions. Outcome measures include joint position sense, kinesthesia, static and dynamic balance performance, and electromyographic (EMG) activity and reaction times of selected lower limb tibialis anterior and peroneus longus muscles.

Conditions

Blood Flow Restriction; Ankle Proprioception

Keywords

ankle; proprioception; blood flow restriction

Outcome Measures

Primary Outcomes (5)

• Change in Ankle Joint Position Sense Error (degrees)

  Absolute error (degrees) between target and reproduced angles during passive and active joint position sense tests in inversion and plantar flexion, measured with an isokinetic dynamometer.

  day 1 and day 2

• Static Balance Performance

  Center of pressure path length (mm) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).

  day 3

• Change in Kinesthesia Threshold (degrees)

  Minimal angular displacement (degrees) at which movement is first perceived in inversion and plantarflexion.

  day 1 and day 2

• Static balance performance

  sway velocity (mm/s) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).

  day 3

• static balance performance

  sway area (mm\^2) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).

  day 3

Secondary Outcomes (3)

• Y-Balance Test Reach Distances (cm)

  day 4

• Peroneus Longus and Tibialis Anterior Reaction Time (ms)

  day 4

• Lower Limb EMG Activity (%MVIC)

  day 4

Study Arms (2)

Blood Flow Restriction

EXPERIMENTAL

Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Other: Blood Flow Restriction

Sham BFR

SHAM COMPARATOR

Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Other: Sham Blood Flow Restriction

Interventions

Blood Flow Restriction OTHER

Arm Description: Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Blood Flow Restriction

Sham Blood Flow Restriction OTHER

Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Sham BFR

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18 and 40 years
• No known neuromuscular or cardiovascular disease

You may not qualify if:

• History or presence of cardiac, coronary artery, or peripheral arterial disease
• Presence or history of varicose veins, hypertension, diabetes mellitus, or pulmonary disease
• History of pulmonary embolism or deep vein thrombosis
• Use of medications affecting the central nervous or cardiovascular systems
• Use of oral contraceptives or anticoagulants
• Pregnancy
• Open wounds or significant scar tissue at the cuff application site
• History of lower extremity musculoskeletal injury or surgery
• Any neurological, vascular, or systemic condition that may interfere with test performance

Sponsors & Collaborators

• Uludag University: lead

Study Sites (1)

Uludag University

Bursa, 16059, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Blood Flow Restriction Therapy

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Officials

• ufuk sekir

  Department of Sports Medicine, Bursa Uludağ University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Model Details: Arm 1: Experimental - Blood Flow Restriction Participants perform balance and proprioception tests under lower-limb blood flow restriction at 60% arterial occlusion pressure. Arm 2: Sham Comparator - Sham Blood Flow Restriction Participants perform the same balance and proprioception tests with sham blood flow restriction at 20 mmHg. This is a randomized crossover study, and all participants complete both conditions in a randomized order.

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: December 29, 2025
• Study Start: September 1, 2025
• Primary Completion: December 30, 2025
• Study Completion: January 10, 2026
• Last Updated: December 29, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)