PCV vs VCV in Low-Flow Anesthesia

NCT07305129 | Completed

• 3 other identifiers: 2023-64hulya topcuserhat ozciftci
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia. This study aimed to compare the effects of low-flow anesthesia on intraoperative respiratory mechanics and early postoperative pulmonary function between PCV and VCV in ASA I-II adult patients.

Conditions

ASA Class I/II Patients; General Anesthetic; Low Flow Anesthesia

Keywords

low-flow anesthesia; pressure-controlled ventilation; volume-controlled ventilation; respiratory mechanics; peak inspiratory pressure; pulmonary function

Outcome Measures

Primary Outcomes (1)

• Mean Ppeak (cmH₂O) at each time point; between-group difference.

  Peak inspiratory pressure will be measured using the anesthesia workstation's built-in pressure monitoring system. Ppeak (cmH₂O) values will be automatically recorded at predefined time points: baseline after intubation, before low-flow transition, and 5, 10, 15, and 30 minutes after transition to low-flow anesthesia. Group comparisons will be reported as mean ± SD and analyzed for intergroup differences.

  From post-intubation baseline until 30 minutes after initiation of low-flow anesthesia (approximately 45 minutes total).

Secondary Outcomes (1)

• Change in inspiratory score (number of balls raised).

  Baseline to 30 minutes after initiation of low-flow anesthesia and Preoperative baseline and postoperative 1 hour

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Hitit University Erol Olçok Training and Research Hospital

You may qualify if:

• \- age 18-65 years and American Society of Anesthesiologists (ASA) physical status I-II.

You may not qualify if:

• morbid obesity (BMI \> 35 kg/m²),
• scoliosis or thoracic deformity,
• restrictive or obstructive lung disease,
• prior thoracic or upper abdominal surgery,
• history of major thoracic trauma or congenital chest wall anomaly,
• active smoking or chronic use of corticosteroids,
• β-agonists, bronchodilators, or antihistamines,
• anticipated difficult airway
• severe hypoxemia (SpO₂ \< 90%) during induction.

Sponsors & Collaborators

• HULYA TOPCU, MD: lead

Study Sites (1)

Hitit University Erol Olçok Training and Research Hospital

Çorum, Çorum, 19030, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assoc. Prof. MD

Study Record Dates

• First Submitted: November 27, 2025
• First Posted: December 26, 2025
• Study Start: July 1, 2023
• Primary Completion: July 15, 2024
• Study Completion: August 1, 2025
• Last Updated: December 26, 2025

Record last verified: 2025-10

Locations

TU (1)