Comparison of Minimum Flow and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery

NCT06520943 | Not Yet Recruiting

• 1 other identifier: TABED1-24-72
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the use of low fresh gas flow (1 L/min) desflurane anesthesia with minimum fresh gas flow (0.5 L/min) desflurane anesthesia in patients undergoing robotic-assisted abdominal surgery. The comparison will be based on hemodynamic and respiratory parameters. The secondary aim of our study is to compare the two different fresh gas flow methods in terms of inhalation agent consumption and soda lime consumption.

Conditions

Minimal Flow Anesthesia; Low Flow Anesthesia; Robotic Assisted Laparoscopic Abdominal Surgery

Outcome Measures

Primary Outcomes (2)

• inspiratory O2 concentration

  inspiratory O2 concentration is measured from anesthesia machine monitor

  from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)

• partial oxygen pressure

  PO2 from blood gas analysis

  from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)

Secondary Outcomes (2)

• desflurane consumption

  3th hour

• changes in liver and kidney function tests from the preoperative values to 48 hours postoperative

  postoperative 1st day

Study Arms (2)

Group 1

After intubation, a fresh gas flow of 3 L/min will be applied for the first 20 minutes and then reduced to 0.5 L/min.

Other: blood gas analysis

Group 2

After intubation, a fresh gas flow of 3 L/min will be applied for the first 20 minutes and then reduced to 1 L/min.

Other: blood gas analysis

Interventions

blood gas analysis OTHER

1. Airway pressure (P plateau, Ppeak) values are taken from the anesthesia device data, 2. BIS (from routine BIS monitoring) 3. Temperature (routinely from pharyngeal temperature probe), 4. Oxygen saturation (routinely from the patient monitor) 5. End-tidal CO₂, 6. inspiratory O₂ concentration, 7. Inspiratory CO2 concentration, 8. inspiratory and expiratory desflurane concentrations, 9. tidal volume, 10. MAC is routinely obtained from anesthesia device data. 11. Blood Gas Analysis (COHgb, Ph, PO2, PCO2, SaO2, HCO3, Base deficit, glucose, lactate)

Group 1; Group 2

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing robotic-assisted abdominal surgery

You may qualify if:

• Patients undergoing robotic-assisted abdominal surgery

You may not qualify if:

• serious cardiac, respiratory, hepatic, renal, or mental disorders;
• hearing problems;
• anxiety, depression, or other psychiatric conditions;
• patient's request to leave the study

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara City Hospital

Ankara, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood gas analysis

MeSH Terms

Interventions

Blood Gas Analysis

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Investigative Techniques

Study Officials

• Betül Güven Aytaç

  Ankara City Hospital Bilkent

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Betül Güven Aytaç

CONTACT

+903125662200; drbguven@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assoc. prof

Study Record Dates

• First Submitted: July 9, 2024
• First Posted: July 25, 2024
• Study Start: July 15, 2024
• Primary Completion: September 1, 2024
• Study Completion: December 31, 2024
• Last Updated: July 25, 2024

Record last verified: 2024-07

Locations

TU (1)