The Effects of Sevoflurane and Desflurane Used in Low-Flow Anesthesia on Thiol Disulfide Homeostasis

NCT06810453 | Completed

• 1 other identifier: 2020/283
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to compare the effects of sevoflurane and desflurane used in low-flow anesthesia on thiol-disulfide homeostasis of patients undergoing general anesthesia.

Conditions

Low Flow Anesthesia

Outcome Measures

Primary Outcomes (1)

• Serum thiol-disulfide homeostasis parameters measurement/ calculation

  Serum thiol-disulfide homeostasis parameters were evaluated using an automated method (3). Homeostasis parameters include disulfide, native thiol (NT) and total thiol (TT) levels, and disulfide/TT, NT/TT, and disulfide/NT ratios. TT and NT levels were measured in μmol/L on a Beckman Coulter AU480 analyzer using a commercial kits (Rel Assay Diagnostics, Türkiye). The amount of disulfide was calculated using the formula ((TT-NT) /2). Then, ratios were calculated as percentages

  A 5 cc venous blood sample was obtained just before the anesthesia induction and at the end of surgery.

Study Arms (2)

sevoflurane

OTHER

sevoflurane low-flow anesthesia

Other: A 5 cc venous blood sample was obtained; Procedure: low-flow anesthesia

desflurane

OTHER

desflurane low-flow anesthesia

Other: A 5 cc venous blood sample was obtained; Procedure: low-flow anesthesia

Interventions

A 5 cc venous blood sample was obtained OTHER

A 5 cc venous blood sample was obtained just before anesthesia induction and at the end of surgery.

desflurane; sevoflurane

low-flow anesthesia PROCEDURE

Low-flow anesthesia, also known as inhalational anesthesia method, is a type of anesthesia that is performed using a semi-closed, rebreathing system containing at least 50% fresh gas. Generally, low-flow anesthesia is used in anesthesia practices because it reduces costs, prevents environmental pollution, increases the humidity of gases, and reduces heat loss. Another important benefit of low-flow is that it requires closer monitoring of patients, which allows for early detection of complications during general anesthesia, thus improving patient safety. Concerns about low-flow anesthesia being used infrequently in the past have been addressed by the introduction of modern anesthesia workstations with sophisticated monitoring and safety features, which have made low-flow anesthesia widely used in most centers.

desflurane; sevoflurane

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who were scheduled to undergo elective total thyroidectomy under general anesthesia

You may not qualify if:

• Patients with diabetes mellitus, alcohol or drug addiction, smoking habits, expected difficult intubation, morbid obesity, chronic obstructive pulmonary disease, cardiovascular disease and those in pregnancy or lactation period were excluded from the study.

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

Elzem Sen

Gaziantep, Sehitkamil, 5327842151, Turkey (Türkiye)

Location

Study Officials

• Elzem Sen, Assoc Prof

  University of Gaziantep

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: January 14, 2025
• First Posted: February 5, 2025
• Study Start: September 1, 2020
• Primary Completion: December 1, 2020
• Study Completion: January 1, 2021
• Last Updated: February 5, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)