The Role of Stress in Cardiac Arrest (Cortizol CPR)

NCT07285915 | Recruiting

• 1 other identifier: Stress
• Study Type: interventional
• Target: 136
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples. Cortisol is produced in larger amounts during periods of ongoing stress and builds up in the hair as it grows. Because hair grows about 1 cm per month, a 3 cm hair sample can show your average stress level over the past three months. The results will be compared with anonymized information from your medical records and the care you received before and during your hospital stay.

Conditions

Cardiac Arrest (CA); Post-Resuscitation Syndrome; Chronic Stress; Heart Attack

Keywords

cardiac arrest; chronic stress; kortizol; hair

Outcome Measures

Primary Outcomes (1)

• Hair cortisol levels assessment in CA patients vs heart attack patients

  Hair cortisol levels assessment in CA patients vs heart attack patients

  Enrollment

Secondary Outcomes (2)

• Correlation of neurological outcomes using the CPC scale in CA patients with hair cortisol levels.

  30 and 90 days after CA

• Correlation between the severity of the post-resuscitation course according to the severity of organ damage (heart, lung, kidneys, brain ) and hair cortisol levels

  30 days after CA

Study Arms (2)

Cardiac arrest

EXPERIMENTAL

Cardiac arrest

Diagnostic Test: Sample of hair

Heart attack

EXPERIMENTAL

Heart attack

Diagnostic Test: Sample of hair

Interventions

Sample of hair DIAGNOSTIC_TEST

Sampling of 3cm of hair due to level of cortizol.

Cardiac arrest; Heart attack

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Cardiac arrest
• Heart attack
• years

You may not qualify if:

• Disapproval patient´s relatives with the study
• Chronical treatment with corticoids and antidepresives

Sponsors & Collaborators

• University Hospital Pilsen: lead

Study Sites (1)

University Hospital Pilsen

Pilsen, Czech Republic, 30100, Czechia

RECRUITING

MeSH Terms

Conditions

Heart Arrest; Myocardial Infarction

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Central Study Contacts

Jana Smalcova, MD, Ph.D.

CONTACT

775 360 017; jana.smalcova@gmail.com

Milan Hromadka, MD, Ph.D.

CONTACT

377 105 840; hromadka@fnplzen.cz

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: December 16, 2025
• Study Start: January 8, 2026
• Primary Completion (Estimated): July 31, 2027
• Study Completion (Estimated): October 31, 2027
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)