On Scene ECPR in Ostrava

NCT07374289 | Recruiting

• 1 other identifier: FNO-KARIM-On-Scene-ECPR
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 2

Brief Summary

On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.

Conditions

Cardiac Arrest (CA); Cardiogenic Shock

Keywords

extracorporeal membrane oxygenation; out-of-hospital cardiac arrest; cardiac arrest; cardiogenic shock

Outcome Measures

Primary Outcomes (3)

• Hospital survival

  Hospital survival will be assessed 30 days after the cardiac arrest

  30 days after the cardiac arrest

• ICU stay

  The length of the Intensive Care Unit (ICU) stay will be assessed in days.

  Through the ICU stay, on average 12 days

• Neurologic outcomes

  Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).

  30 days after the cardiac arrest

Secondary Outcomes (4)

• Collapse to ECMO interval

  One hour

• Collapse to ECMO interval

  From the collapse (cardiac arrest) to ECMO initiation

• Long-term outcome - Survival

  6 months after the collapse

• Long-term outcome - Quality of Life

  6 months after the collapse

Study Arms (2)

ECPR on scene

EXPERIMENTAL

On-scene ECPR cannulation by mobile ECMO team according to protocol if the location of the arrest and circumstances appear to be suitable (distance from the ECMO centre, transport logistics, in an ambulance/at home, etc.)

Procedure: Prehospital ECMO cannulation on scene of cardiac arrest

ECPR in hospital

ACTIVE COMPARATOR

Hospital ECPR cannulation at Emergency Department by ECMO team accord-ing to protocol if a on scene ECPR call-out was not indicated.

Procedure: Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation

Interventions

Prehospital ECMO cannulation on scene of cardiac arrest PROCEDURE

ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.

ECPR on scene

Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation PROCEDURE

ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.

ECPR in hospital

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Presumed cardiac aetiology of the cardiac arrest
• Witnessed collapse
• Bystander CPR
• Estimated age ≤ 70 years
• Body weight ≥15 Kg

You may not qualify if:

• Known terminal malignant disease
• Known terminal chronic disease

Sponsors & Collaborators

• University Hospital Ostrava: lead
• Emergency Medical Services, Moravian-Silesian Region: collaborator

Study Sites (2)

Emergency Medical Services, Moravian-Silesian Region

Ostrava, Moravian-Silesian Region, 700 30, Czechia

RECRUITING

University Hospital Ostrava

Ostrava, Moravian-Silesian Region, 708 52, Czechia

RECRUITING

MeSH Terms

Conditions

Heart Arrest; Shock, Cardiogenic; Out-of-Hospital Cardiac Arrest

Interventions

Parturition

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Myocardial Infarction; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Shock

Intervention Hierarchy (Ancestors)

Pregnancy; Reproduction; Reproductive Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Study Officials

• Filip Burša, MD, PhD, EDEC

  University Hospital Ostrava

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jiří Hynčica

CONTACT

+42059737; jiri.hyncica@fno.cz

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Masking Details: No masking will be used in the study.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The study subjects will be enrolled in two parallel arms

Study Record Dates

• First Submitted: January 9, 2026
• First Posted: January 28, 2026
• Study Start: January 30, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (2)