What is the Role of Triglyceride-glucose Index as a Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients?

NCT07279922 | Not Yet Recruiting DMC

• 1 other identifier: TyG-CKD
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the role of the triglyceride-glucose (TyG) index as a predictive marker for insulin resistance in pre-diabetic patients with chronic kidney disease (CKD), and to investigate its potential utility as a simple, non-invasive alternative to traditional insulin resistance assessment methods.

Conditions

Chronic Kidney Disease; Pre Diabetes

Outcome Measures

Primary Outcomes (1)

• Diagnostic performance of TyG index

  Diagnostic performance of TyG index in predicting prediabetics and diabetic patients.

  2 years

Interventions

Triglyceride-glucose index DIAGNOSTIC_TEST

Triglyceride-glucose index calculation according to TyG index=In\[Triglycerides(mg/dl)×Fasting Glucose(mg/dl)/2\]

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged ≥18 years with medical history free from renal dysfunction or with renal dysfunction (CKD stages 2\_5 based on KDIGO guidelines)

You may qualify if:

• Adults aged ≥18 years
• Patients with medical history free from renal dysfunction
• Patients with renal dysfunction (CKD stages 2\_5 based on KDIGO guidelines)
• No previous diagnosis of diabetes mellitus
• Provided informed consent

You may not qualify if:

• Known type 1 or type 2 diabetes mellitus
• Acute kidney injury
• Use of steroids or medications that affect glucose and lipid metabolism
• Pregnancy
• Active infections
• Malignancy

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Glucose Intolerance

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Hyperglycemia; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at internal medicine department

Study Record Dates

• First Submitted: December 1, 2025
• First Posted: December 12, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: December 12, 2025

Record last verified: 2025-12