Impact of Partially Replacing Wheat With Millets or Bengal Gram Flour in Rotis on Glycemia and Prediabetes Reversal

NCT07205705 | Not Yet Recruiting DMC

• 2 other identifiers: F.no.2.1/FCDOC/EC/HAO/2022-23IIRPSG-2025-01-00736
• Study Type: interventional
• Target: 140
• Locations: 0 countries
• Sites: N/A

Brief Summary

There is limited research on the impact of millets on glycemia, and it remains unclear whether partially replacing wheat in rotis with low glycemic index millets or Bengal gram flour offers greater glycemic benefits compared to whole wheat. This approach has the potential to reduce postprandial and overall glycemia, supporting the reversal of prediabetes through dietary modification alone. This study introduces a novel formulation of rotis using 50:50 blends of wheat with either barnyard millet, barley, or Bengal gram flour, aiming to improve glycemic control without compromising taste. Glycemic response is assessed through a combination of meal tolerance tests, continuous glucose monitoring, and a three-month dietary intervention, providing both immediate and long-term data. Additionally, the study includes a comprehensive metabolic evaluation by measuring serum insulin, inflammatory markers, and free fatty acids key indicators in the progression of prediabetes. Conducted as a randomized controlled trial with 80 participants across four arms (20 per arm), the study comprises three phases: Phase I evaluates immediate glycemic response through a meal tolerance test; Phase II uses continuous glucose monitoring over three days to monitor fluctuations in glucose levels; and Phase III, with 140 participants, assesses the long-term impact of the dietary intervention over three months. The primary objectives are to determine the effect of the interventions on glycemic response and HbA1c, with an expected outcome of a 10% reduction in the area under the curve for overall and postprandial glucose in Phases I and II, and a 10% reduction in HbA1c in Phase III.

Conditions

Pre Diabetes

Outcome Measures

Primary Outcomes (1)

• HbA1c (%)

  3 months

Secondary Outcomes (1)

• fasting glucose mg/dL) and satiety

  3 months

Study Arms (2)

Control Group

NO INTERVENTION

Wheat

Intervention Group

EXPERIMENTAL

Wheat + Barnyard millet/ Wheat +Barley/ wheat+ Bengal gram flour

Dietary Supplement: Millet

Interventions

Millet DIETARY_SUPPLEMENT

Wheat + Barnyard millet/ Wheat +Barley/ wheat+ Bengal gram flour

Intervention Group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 to 60 years
• Prediabetes as diagnosed on oral glucose tolerance test (OGTT): Fasting blood glucose ≥100mg/dl and \<126 mg/dl and/or 2-h plasma glucose ≥140mg/dl and \<200mg/dl (after ingestion of 75 gram anhydrous oral glucose).

You may not qualify if:

• Acute infections and advanced end-organ damage
• History of hepatitis or pancreatitis, abnormal liver and renal functions
• Recent (\<3 months) changes in weight (≥5%) and/or weight-changing medications
• Any known allergy to wheat or any other grain
• Subjects with uncontrolled hypothyroidism or hypertension
• On any drug causing weight gain or weight loss

Sponsors & Collaborators

• Diabetes Foundation, India: lead

MeSH Terms

Conditions

Glucose Intolerance

Interventions

foxtail millet trypsin inhibitor III

Condition Hierarchy (Ancestors)

Hyperglycemia; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Anoop Misra, M.D.

CONTACT

011-49101222; anoopmisra@gmail.co

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 10, 2025
• First Posted: October 3, 2025
• Study Start: November 15, 2025
• Primary Completion (Estimated): September 15, 2027
• Study Completion (Estimated): November 20, 2027
• Last Updated: October 3, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share