Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment

NCT07438002 | Recruiting DMC

• 1 other identifier: 573CET
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group

Conditions

Chronic Kidney Disease

Keywords

Nephrology; exercise; physical activity

Outcome Measures

Primary Outcomes (7)

• Gait speed (6MWT)

  • Assess the effect of exercise on physical performance and quality of life on pa-tients with chronic kidney disease from stage 1 to end stage renal disease on maintenance haemodialysis or on conservative treatment

  through study completion, an average of 1 year

• Physical performance (SPPB)

  through study completion, an average of 1 year

• Cardiopulmonary capacity (CPET)

  through study completion, an average of 1 year

• Lower limbs strength (1-RM)

  through study completion, an average of 1 year

• Maximum isometric strength of the upper limb (hand grip)

  through study completion, an average of 1 year

• Daily physical activity amount (IPAQ)

  through study completion, an average of 1 year

• Quality of life (SF36)

  through study completion, an average of 1 year

Secondary Outcomes (6)

• Nutritional status (24HR, FFQ)

  through study completion, an average of 1 year

• Body composition (DEXA, BIVA)

  through study completion, an average of 1 year

• Psychological and psychosocial conditions (BDI, MMSE)

  through study completion, an average of 1 year

• Hemodynamic and vascular functions (SV, CO, HR, FBF, FMD, sPLM)

  through study completion, an average of 1 year

• Muscular oxygen extraction (NIRS)

  through study completion, an average of 1 year

Other Outcomes (2)

• effect of physical activity on mitochondrial activity

  through study completion, an average of 1 year

• Effect of physical activity on mitochondrial activity

  through study completion, an average of 1 year

Study Arms (2)

combined exercise

EXPERIMENTAL

participants will undergo a combined endurance and resistance exercise training

Other: Exercise

control group

ACTIVE COMPARATOR

participants performs outcome measures sessions only, including blood sample collection.

Other: control

Interventions

Exercise OTHER

All participants will be involved in the exercise training three times per week for 24 weeks: endurance exercise training, resistant exercise training

combined exercise

control OTHER

outcome measures

control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Signature of the informed consent
• Patients with CKD stage 1 to 5 under conservative treatment
• Patients undergoing chronic hemodialysis for at least 3 months
• Age ≥ 18

You may not qualify if:

• Severe cardiovascular disease (NYHA class IV or hypertension class III)
• TIA or myocardial ischemia within the last three months
• Anatomical limitations
• Health conditions detected during the stress test (CPET)

Sponsors & Collaborators

• Casa di Cura Dott. Pederzoli: lead

Study Sites (1)

Ospedale P. Pederzoli Casa di Cura Privata S.p.A.

Peschiera del Garda, Verona, 37019, Italy

RECRUITING

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 13, 2026
• First Posted: February 27, 2026
• Study Start: September 2, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)