NCT07273448

Brief Summary

Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular complications and biliary complications; and explore relevant risk factors affecting prognosis.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
45mo left

Started Jan 2014

Longer than P75 for all trials

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress77%
Jan 2014Dec 2029

Study Start

First participant enrolled

January 1, 2014

Completed
11.9 years until next milestone

First Submitted

Initial submission to the registry

November 20, 2025

Completed
19 days until next milestone

First Posted

Study publicly available on registry

December 9, 2025

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2028

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2029

Last Updated

December 9, 2025

Status Verified

November 1, 2025

Enrollment Period

15 years

First QC Date

November 20, 2025

Last Update Submit

November 27, 2025

Conditions

ABO IncompatibilityLiver Transplant SurgeryLiving Donor Liver Transplantation

Outcome Measures

Primary Outcomes (2)

  • Postoperative survival rate

    Minimum follow-up period of 1 year postoperatively.

  • incidence of acute rejection

    Within 1 year postoperatively

Secondary Outcomes (2)

  • Vascular complications

    Within 1 year postoperatively

  • Biliary complications

    Within 1 year postoperatively

Study Arms (1)

ABO-Incompatible Living Donor Liver Transplantation Patients

Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular complications and biliary complications; and explore relevant risk factors affecting prognosis.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All eligible patients who underwent ABO-incompatible living donor liver transplantation between January 1, 2014 and December 31, 2028 and met the inclusion and exclusion criteria.

You may qualify if:

  • Underwent ABO-incompatible living donor liver transplantation
  • Complete and intact clinical and follow-up data

You may not qualify if:

  • Non-primary liver transplantation
  • Combined other organ transplantation
  • Incomplete clinical data or loss to follow-up

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 20, 2025

First Posted

December 9, 2025

Study Start

January 1, 2014

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2029

Last Updated

December 9, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share