NCT07250919

Brief Summary

This observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation (LT). The study aims to answer the following question: Does gender mismatch lower the possibility of survival after liver transplantation? Participants demonstrate gender dicrepancies between donors and recipients as regular concept in LT. The retrospective cohort study investigates the impact over a long-term follow up of 10 years.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,146

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2014

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2014

Completed
8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2022

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2024

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

November 18, 2025

Completed
8 days until next milestone

First Posted

Study publicly available on registry

November 26, 2025

Completed
Last Updated

February 13, 2026

Status Verified

October 1, 2025

Enrollment Period

8 years

First QC Date

November 18, 2025

Last Update Submit

February 10, 2026

Conditions

Patient SurvivalGraft SurvivalLiver Disease (Alcoholic or Not)Liver Transplant Surgery

Keywords

liver transplantationpatient survivalgender mismatchlong-term outcomeorgan allocation

Outcome Measures

Primary Outcomes (1)

  • Patient survival

    Overall survival of patients who underwent liver transplantation at the Ajmera transplant centre toronto between 2014 and 2022

    Liver transplantation between 01.01.2014 and 01.01.2022, Patient Survival: observatory period between 01.01.2014 and 01.01.2024

Study Arms (2)

GM +

Liver transplant recipients with gender mismatch

GM -

Liver transplant recipients without gender mismatch

Eligibility Criteria

Age18 Years+
Sexall(Gender-based eligibility)
Gender Eligibility DetailsSince gender discrepancies are studied, the participant are identified by their biological gender, including male and female.
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients who underwent liver transplantation at who at the Ajmera transplant centre, Toronto between 2014 and 2022

You may qualify if:

  • Patients over the age of 18

You may not qualify if:

  • Cases of retransplantation
  • Combined organ transplantation
  • Cases with \>30% of missing values

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto

Toronto, Ontario, Canada

Location

Related Publications (1)

  • Ghinolfi D, Melandro F, Torri F, Martinelli C, Cappello V, Babboni S, Silvestrini B, De Simone P, Basta G, Del Turco S. Extended criteria grafts and emerging therapeutics strategy in liver transplantation. The unstable balance between damage and repair. Transplant Rev (Orlando). 2021 Dec;35(4):100639. doi: 10.1016/j.trre.2021.100639. Epub 2021 Jul 16.

    PMID: 34303259BACKGROUND

MeSH Terms

Conditions

Liver Diseases

Condition Hierarchy (Ancestors)

Digestive System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 18, 2025

First Posted

November 26, 2025

Study Start

January 1, 2014

Primary Completion

January 1, 2022

Study Completion

January 1, 2024

Last Updated

February 13, 2026

Record last verified: 2025-10

Locations

CA(1)