A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation

NCT06865612 | Completed

• 1 other identifier: 2024-05-025
• Study Type: observational
• Target: 109
• Locations: 1 country
• Sites: 1

Brief Summary

Accurate preoperative graft volume assessment is crucial for successful living donor liver transplantation (LDLT). Although manual and automated computed tomography (CT) volume measurement methods using various volumetric tools are widely used, their accuracy remains uncertain. This study aimed to determine the optimal dry weight correction factor for each method to enhance the prediction of actual graft weight (AGW) and compare the accuracy of different methods.

Conditions

Living Donor Liver Transplantation; Liver Failure

Outcome Measures

Primary Outcomes (1)

• Accuracy of preoperative estimated graft volume (EGV) compared to actual graft weight (AGW)

  The accuracy of preoperative donor CT liver volumetry will be assessed by comparing estimated graft volume (EGV) obtained from three methods (automated, semi-automated, manual) with the actual graft weight (AGW) measured intraoperatively. The error ratio between EGV and AGW will be calculated for each method.

  From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

Secondary Outcomes (1)

• Determination of the optimal dry weight correction factor for each volumetry method

  From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

Study Arms (1)

Donors

Patients who received hepatectomy for the living donor liver transplantation.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes patients who underwent hepatectomy for living donor liver transplantation performed at Chungnam National University Hospital. Data will be retrospectively reviewed to compare preoperative estimated graft volume (EGV) to actual graft weight (AGW).

You may qualify if:

• Patients who underwent hepatectomy for living donor liver transplantation performed by the Department of Surgery at Chungnam National University Hospital under the supervision of the principal investigator.

You may not qualify if:

• Patients deemed unsuitable for participation in this clinical study by the investigator.

Sponsors & Collaborators

• Chungnam National University Hospital: lead

Study Sites (1)

Chungnam National University Hospital

Daejeon, South Korea

Location

MeSH Terms

Conditions

Liver Failure

Condition Hierarchy (Ancestors)

Hepatic Insufficiency; Liver Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 6, 2025
• First Posted: March 10, 2025
• Study Start: November 1, 2011
• Primary Completion: December 31, 2024
• Study Completion: January 31, 2025
• Last Updated: March 10, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)