Efficacy of Loco-regional Treatment for Hepatocellular Carcinoma Prior to Living Donor Liver Transplantation in Egypt

NCT02990351 | Completed

• 1 other identifier: HCC and liver transplantation
• Study Type: observational
• Target: 29
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aimed to analyze the outcomes of loco-regional treatment prior Living Donor Liver Transplantation in patients with HCC.

Conditions

Hepatocellular Carcinoma (HCC); Living Donor Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• Radiological Response ( complete / partial / tumour progression)in the Radiology (CT/ MRI) before transplantation

  the success of loco-regional therapy for hepatocellular carcinoma in term of radiological complete or partial response in the last spiral triphasic abdominal CT and /or MRI before transpalantation

  3 months

Secondary Outcomes (1)

• the degree of accuracy between the last CT/ MRI and the pathology of explant in term of number , size and ablation (complete necrosis ) for HCC

  3 months

Study Arms (1)

HCC patients

29 HCC patients who had loco regional therapies for HCC were analyzed. Twenty patients met the Milan criteria (68.97%) \& 4 (13.8%) were beyond Milan but met UCSF criteria and 5 were exceeding UCSF criteria (17.2%).All patients underwent preoperative LRTs, The protocol of bridging/down staging, methods, duration of follow up, the number of the patients who were successfully down-staged before LT and their outcomes after LT were recorded.

Procedure: loco regional therapies for HCC

Interventions

loco regional therapies for HCC PROCEDURE

29 HCC patients received locoregonal therapy as a bridging therapy for those who were within milan and as downstaging for those were initially beyond milan. The main LRT types used for our patients were TACE and or RFA and microwave ablation

HCC patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult Egyptian patients prepared for living donor liver transplantation , at Ain Shams Centre for Organ Transplantation (ASCOT) , Cairo Egypt

You may qualify if:

• Adult patients 18-65 years
• Patients transplanted for HCC within Milan and UCSF criteria who underwent pre transplant bridge or down staging treatment for HCC

You may not qualify if:

• Tumor progression on the waiting list
• Vascular invasion by imaging studies
• Extrahepatic or lymph node metastasis

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate profesor of tropical medicine , Ain Shams university

Study Record Dates

• First Submitted: December 4, 2016
• First Posted: December 13, 2016
• Study Start: December 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: December 13, 2016

Record last verified: 2016-12