Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma

NCT07270835 | Recruiting Phase 4

• 1 other identifier: HLH-003
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

For patients who met the inclusion criteria, treatment regimens were administered: Rituximab 375 mg/m², intravenously, once weekly for 4 weeks. Zanubrutinib 160 mg, orally, twice daily for 4 weeks. Combined drugs: prednisone 100 mg/m²/d, orally, d1-5; Ruxolitinib 15mg bid orally; With/without emapalumab as appropriate.

Conditions

Hemophagocytic Lymphohistiocytosis; B Cell Lymphoma

Outcome Measures

Primary Outcomes (2)

• response rate of HLH after 4 weeks of treatment

  RR will be evaluated according to the response evaluation criteria recommended by the International Histiocyte Society.

  after 4 weeks

• OS at week 8

  overall survival after 8 weeks of treatment

  after 8 weeks

Secondary Outcomes (2)

• AE

  till the end of 4 weeks

• OS

  at 4/8/12/24 weeks

Study Arms (1)

intervention group

EXPERIMENTAL

Rituximab 375 mg/m², intravenously, once weekly for 4 weeks (may be extended or adjusted according to clinical response). Zanubrutinib: 160 mg, orally, twice daily for 4 weeks as for rutuximab. Dose can be adjusted or extended according to tolerance and efficacy. When ≥3 grade hematological or intolerable non-hematological toxicity occur, zanubrutinib or rituximab will be suspended, and the dose will be reduced or resumed according to the toxicity grade after recovery. The dose of zanubrutinib should be adjusted according to the manufacturer's label with concomitant use of strong CYP3A inhibitor/inducer. Combined drugs: prednisone 100 mg/m²/d, orally, d1-5; Ruxolitinib 15mg bid orally; With/without emapalumab as appropriate.

Drug: Rituximab; Drug: Zanubrutinib

Interventions

Rituximab DRUG

375 mg/m², intravenously, once weekly for 4 weeks

Also known as: HALPRYZA

intervention group

Zanubrutinib DRUG

160 mg, orally, twice daily for 4 weeks as for rutuximab.

Also known as: Brukinsa

intervention group

Eligibility Criteria

• Age: 14 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• According to the diagnostic criteria of HLH-04, the patients meet the diagnostic criteria of HLH;
• HLH patients with definite or highly suspected evidence of B-cell lymphoma; Or HLH patients whose bone marrow flow cytometry show an increased proportion of CD20-positive B cells;
• Age of 14-80 years old, both sexes;
• Predicted survival beyond 1 month;
• Baseline serum creatinine ≤1.5 times ULN; Fibrinogen could be corrected to ≥0.6g/L by infusion;
• Negative serum HIV antibody; Either negative for HCV antibodies or positive for HCV antibodies but negative for HCV RNA. HBV surface antigen and HBV core antibody were negative. If any of the above was positive, HBV DNA titer in peripheral blood should be tested, and the titer was less than 1×10\^3 copies /ml;
• Left ventricular ejection fraction (LVEF) ≥50% measured by echocardiography;
• The patient have no serious and uncontrollable infections, such as pulmonary infection, intestinal infection, and sepsis;
• Women of childbearing age must be confirmed to be not pregnant by pregnancy test and willing to take effective measures to prevent pregnancy during the study period and ≥12 months after the last dose; Pregnant and lactating women cannot participate; All male subjects took contraceptive measures during the trial and ≥3 months after the last dose;
• Patients should be able to sign informed consent.

You may not qualify if:

• Patients with known severe allergy to rituximab, zanubrutinib, or other BTK inhibitors;
• Severe active infections (including bacterial, viral or fungal infections) or uncontrolled co-infections;
• Severe organ dysfunction including NYHA class III-IV heart failure or severe arrhythmia; Liver function: ALT or AST \>5 times the upper limit, or severe cirrhosis; Renal function: CrCl \<30 mL/min or severe renal insufficiency;
• Combined with other malignant tumors and the expected survival time was less than 3 months;
• Have received other experimental drugs and had not completed the drug washout period;
• Pregnant or lactating women, or unwilling to use effective contraception;
• any condition that would not be suitable for participation in the study or that might affect adherence, follow-up, or safety assessment, as judged by the investigator.

Sponsors & Collaborators

• The First Affiliated Hospital of Soochow University: lead

Study Sites (1)

The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

RECRUITING

MeSH Terms

Conditions

Lymphohistiocytosis, Hemophagocytic; Lymphoma, B-Cell

Interventions

Rituximab; zanubrutinib

Condition Hierarchy (Ancestors)

Histiocytosis, Non-Langerhans-Cell; Histiocytosis; Lymphatic Diseases; Hemic and Lymphatic Diseases; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Immunoproliferative Disorders; Immune System Diseases

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, Murine-Derived; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins

Study Officials

• Xuefeng He, doctor

  department of hematology, The First Affiliated Hospital of Soochow University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xuefeng He, doctor

CONTACT

86-18914031640; hexuefeng@suda.edu.cn

Fei Zhou, doctor

CONTACT

86-15051425673; zhoufei@suda.edu.cn

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: December 8, 2025
• Study Start: November 1, 2025
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: December 8, 2025

Record last verified: 2025-11

Locations

CN (1)