Key Insights

Highlights

Success Rate

67% trial completion

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 27/100

Termination Rate

10.8%

4 terminated out of 37 trials

Success Rate

66.7%

-19.8% vs benchmark

Late-Stage Pipeline

32%

12 trials in Phase 3/4

Results Transparency

88%

7 of 8 completed with results

Key Signals

7 with results67% success

Data Visualizations

Phase Distribution

33Total
Not Applicable (6)
P 1 (7)
P 2 (8)
P 3 (11)
P 4 (1)

Trial Status

Unknown14
Completed8
Not Yet Recruiting4
Active Not Recruiting4
Terminated4
Recruiting2

Trial Success Rate

66.7%

Benchmark: 86.5%

Based on 8 completed trials

Clinical Trials (37)

Showing 20 of 20 trials
NCT04551131Phase 1Active Not RecruitingPrimary

Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

NCT07497438Phase 3Not Yet RecruitingPrimary

Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis

NCT01821781Phase 2Active Not Recruiting

Immune Disorder HSCT Protocol

NCT01652092Not ApplicableActive Not Recruiting

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

NCT07270835Phase 4RecruitingPrimary

Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma

NCT01494103Phase 1Active Not Recruiting

Administration of Donor T Cells With the Caspase-9 Suicide Gene

NCT01793168Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

NCT03259230CompletedPrimary

Evaluation of IFNγ and Inflammatory Mediators in Patients With Malignancy-Associated Hemophagocytic Lymphohistiocytosis

NCT02231710Phase 1Terminated

Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases

NCT06131489Not Yet RecruitingPrimary

Segmental Resection Combined With DEP Regimen for EBV-HLH Patients With Intestinal Involvement

NCT06038422Phase 3Unknown

GTP Regimen in the Treatment of Refractory/Recurrent HLH

NCT05775705Phase 3Not Yet Recruiting

L-DEP Regimen Combined With PD-1 Antibody as Induction Therapy for Epstein-Barr Virus-positive LA-HLH

NCT03510650CompletedPrimary

Diagnostic Biomarkers for Adult Hemophagocytic Lymphohistiocytosis in Critically Ill Patients (HEMICU)

NCT01998633Phase 2CompletedPrimary

Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)

NCT05546060Phase 1UnknownPrimary

Efficacy and Safety of Venetoclax Combined With Dexamethasone and Etoposide in HLH

NCT02069899Phase 2CompletedPrimary

A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody

NCT05315336Phase 3Not Yet RecruitingPrimary

L-DEP/DEP Regimen and PD-1 Antibody as a Treatment for Relapse/Refractory EBV-HLH

NCT02007239Phase 2WithdrawnPrimary

Tocilizumab and Hemophagocytic Lymphohistiocytosis (HLH)

NCT05164978Not ApplicableUnknownPrimary

DEP Combine With PD-1 Antibody as an Treatment for EBV-HLH

NCT05137522Not ApplicableUnknown

Chidamide Combines With VP-16 and Methylprednisolone in the Treatment of HLH

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