A Comparative Study of Platelet-Rich Plasma and Normal Saline Dressings in the Treatment of Chronic Wounds (PRP-NS Wound T)

NCT06849232 | Completed

• 2 other identifiers: 2381/DME/QAMC Bahawalpur2381/DME/QAMC
• Study Type: interventional
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effectiveness of Platelet-Rich Plasma (PRP) dressings versus Normal Saline dressings in the treatment of chronic wounds. Chronic wounds are slow-healing wounds that can cause significant discomfort, increase the risk of infections, and impact a patient's quality of life. Platelet-Rich Plasma (PRP) is derived from the patient's own blood and contains growth factors that may help promote faster wound healing. On the other hand, Normal Saline dressings are commonly used as a standard wound care approach. Participants in this study will be randomly assigned to receive either PRP dressings or normal saline dressings. The healing progress of their wounds will be monitored over a specified period to determine which treatment leads to better and faster healing. The findings from this study may help improve wound care management and provide evidence for using PRP as an effective treatment for chronic wounds.

Conditions

Wound Healing

Outcome Measures

Primary Outcomes (1)

• Wound Healing Rate

  April 17, 2024, to October 16, 2024

Study Arms (2)

PRP Dressing Group

EXPERIMENTAL

wounds were first cleaned with normal saline, followed by the injection of PRP, prepared from the patient's own blood by the hematology department, into the surrounding wound area twice weekly

Procedure: Platelet-Rich Plasma (PRP) Injections

Normal Saline Dressing Group

ACTIVE COMPARATOR

Procedure: Platelet-Rich Plasma (PRP) Injections

Interventions

Platelet-Rich Plasma (PRP) Injections PROCEDURE

wounds were first cleaned with normal saline, followed by the injection of PRP, prepared from the patient's own blood by the hematology department, into the surrounding wound area twice weekly

Normal Saline Dressing Group; PRP Dressing Group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years of either gender were included if they had a chronic wound persisting for at least six weeks and with a size of at least 2 × 2 cm.

You may not qualify if:

• Patients were excluded if their wounds had existed for less than six weeks, if they had a previous history of PRP dressing use, or if they had documented hypersensitivity to PRP.

Sponsors & Collaborators

• Quaid-e-Azam Medical College: lead

Study Sites (1)

Bahawal Victoria Hospital

Bahawalpur, Punjab Province, 63100, Pakistan

Location

MeSH Terms

Interventions

Injections

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Therapeutics

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Surgery

Study Record Dates

• First Submitted: February 8, 2025
• First Posted: February 27, 2025
• Study Start: April 17, 2024
• Primary Completion: April 17, 2024
• Study Completion: April 17, 2024
• Last Updated: February 27, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)