Assessment of the Glycemic Responses to Nutritional Products-INQ-2526

NCT07243743 | Completed

• 1 other identifier: 25REX0091089 - GLIN#5
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This study assesses the glycemic responses to nutritional products. During a study visit fasted subjects will consume a serving of the reference product or the test product. Capillary blood samples will be taken at baseline and at several time-points over a 2-hr period. Several nutritional products will be tested over time.

Conditions

Glycemic Response

Keywords

Glycemic response; Glycemic Index; nutritional products; healthy individuals

Outcome Measures

Primary Outcomes (1)

• The glycemic index of nutritional products

  From enrollment to the end of treatment at about 6 weeks

Secondary Outcomes (2)

• 1. The postprandial glucose levels at each time point after each test product compared with the mean of the 3 references

  From enrollment to the end of treatment at about 6 weeks

• 2. The postprandial incremental area under the curve (iAUC) after each test product compared with the mean of the 3 references

  From enrollment to the end of treatment at about 6 weeks

Study Arms (5)

Arm 1

OTHER

All subjects will receive all interventions during the trial. The order of the Nutritional products will be randomized.

Dietary Supplement: First Reference Product

Arm 2

OTHER

All subjects will receive all interventions during the trial. The order of the Nutritional products will be randomized.

Dietary Supplement: Second Reference Product

Arm 3

OTHER

All subjects will receive all interventions during the trial. The order of the Nutritional products will be randomized.

Dietary Supplement: Third Reference Product

Arm 4

OTHER

All subjects will receive all interventions during the trial. The order of the Nutritional products will be randomized.

Dietary Supplement: First Concept Product

Arm 5

OTHER

All subjects will receive all interventions during the trial. The order of the Nutritional products will be randomized.

Dietary Supplement: Second Concept Product

Interventions

First Reference Product DIETARY_SUPPLEMENT

dextrose (containing 10 grams of carbohydrates)

Arm 1

Second Reference Product DIETARY_SUPPLEMENT

dextrose (containing 10 grams of carbohydrates)

Arm 2

Third Reference Product DIETARY_SUPPLEMENT

dextrose (containing 10 grams of carbohydrates)

Arm 3

First Concept Product DIETARY_SUPPLEMENT

high protein beverage no sugar 1

Arm 4

Second Concept Product DIETARY_SUPPLEMENT

high protein beverage no sugar 2

Arm 5

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 and ≤ 65 years
• Body mass index (BMI) between 18.5 and 27 kg/m²

You may not qualify if:

• Fasting Glucose ≥6.1 at screening visit
• Known history of gastrointestinal disease, bariatric surgery, AIDS, hepatitis, a history or presence of clinically important endocrine (including Type 1 or Type 2 diabetes mellitus), or any condition which might, in the opinion of the medical director either: 1) make participation dangerous to the subject or to others, or 2)affect the results.
• Use of medications known to influence carbohydrate metabolism, gastrointestinal function or appetite, including, but not limited to adrenergic blockers, diuretics, thiazolidinediones, metformin and systemic corticosteroids within 4 weeks of the screening visit, or any medication which might, in the opinion of the medical director either: 1) make participation dangerous to the subject or to others, or 2) affect the results.
• Major trauma or surgical event within 3 months of screening.
• Known intolerance, sensitivity or allergy to test products.
• Extreme dietary habits, as judged by the Investigator (i.e. Atkins diet, very high protein diets, etc.).
• History of cancer in the prior two years, except for non-melanoma skin cancer.

Sponsors & Collaborators

• Nutricia Research: lead

Study Sites (1)

INQUIS Clinical Research, Ltd , 20 Victoria Street, 3rd Floor

Toronto, Ontario, M5C 2N8, Canada

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: 2 test products and 3 controls, in total 5 products

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 24, 2025
• Study Start: October 17, 2025
• Primary Completion: December 3, 2025
• Study Completion: December 3, 2025
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)