Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users

NCT07215065 | Recruiting DMC

• 2 other identifiers: OSU-25119NCI-2025-06572
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates heavy metal exposure in young adults who use electronic cigarettes.

Conditions

Heavy Metal Exposure From Vaping

Outcome Measures

Primary Outcomes (4)

• Heavy metal concentration in the saliva of e-cigarette users

  Identify and quantify HM concentrations in the saliva among all participants in the sample before and after their 30 minute vaping session.

  Baseline, Immediately Following Vaping Session

• Spirometry to Measure the Change From Baseline in Forced Vital Capacity (FVC)

  Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.

  Baseline, Immediately Following Vaping Session

• Spirometry to Measure the Change From Baseline in Forced Expiratory Volume in One Second (FEV1)

  Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.

  Baseline, Immediately Following Vaping Session

• E-cigarette puffing behavior

  E-cigarette puffing behavior will be measured with a topography device that records frequency, duration, and flow rate of e-cigarette puffs. These measures are combined to inform the overall measure of e-cigarette puffing behavior.

  Up to 30 minutes

Study Arms (1)

Observational

Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

Non-Interventional Study

Also known as: Non-Interventional Observational Study

Observational

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Young adults (aged 18 - 29 years) who are established and current EC users.

You may qualify if:

• Aged 18-29 years
• Established electronic cigarette (EC) user (participant uses ECs on a daily/weekly basis \[used on ≥ 5 days in past 30-days\] for the past 3 months)
• Willing to abstain from nicotine for at least 12 hours before the laboratory visit
• Willing to not eat food or drink water/beverages for at least 30 minutes before the laboratory visit \[required for salivary collection\]
• Utilize 4th generation EC products (pod-mod or disposable EC products; e.g., JUUL, Hyde)
• Must be able to read and write in English

You may not qualify if:

• Recently COVID-19+ (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (within the past 6 months)
• Attempting to quit the use of ECs
• Is pregnant, planning on becoming pregnant and/or breastfeeding \[will be verified using a urine pregnancy test\]
• Self-reported severe or significant psychological and/or psychiatric conditions \[e.g., not currently receiving treatment/medication; only past and/or stable conditions will be allowed\]
• A history of cardiac events and/or distress within the past 3 months
• Diagnosed with a chronic, serious lung disease or current infection (e.g., pneumonia, pulmonary edema)
• Are deaf, hard of hearing, or have a severe motor disability

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead

Study Sites (1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Related Links

• The Jamesline

Study Officials

• Alayna P Tackett, PhD

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

The Ohio State University Comprehensive Cancer Center

CONTACT

800-293-5066; OSUCCCClinicaltrials@osumc.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 8, 2025
• First Posted: October 10, 2025
• Study Start: October 22, 2025
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): May 31, 2026
• Last Updated: February 17, 2026

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)