Investigating Memory and Physical Activity After Cancer Treatment in Survivors of Adolescent and Young Adult Cancers

NCT06880861 | Recruiting

• 2 other identifiers: 24-008654NCI-2025-01193
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates relationships among physical activity, thinking, and memory after cancer treatment in survivors of adolescent and young adult cancers.

Conditions

Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm

Keywords

cancer; adolescent; young adult; cognition; memory; exercise; physical activity

Outcome Measures

Primary Outcomes (1)

• Cognitive performance on Stroop task

  Assessed using the CNS Vital Signs computerized testing platform ("brain games"). CNS Vital Signs is a computerized neuropsychological/neurocognitive assessment platform used by clinicians and researchers to objectively evaluate brain function and neurocognitive status, offering a range of tests and tools for assessment and management of various neurological and behavioral conditions.

  Up to 4 weeks

Secondary Outcomes (9)

• Cognitive performance on Visual Memory Test

  2 weeks

• Cognitive performance on Verbal Memory Test

  2 weeks

• Cognitive performance on Symbol Digit Coding Test

  2 weeks

• Cognitive performance on Shifting Attention Test

  2 weeks

• Cognitive performance on Continuous Performance Test

  Up to 4 weeks

Study Arms (1)

Observational

Patients complete questionnaires and cognitive tasks and wear an activity monitor to measure physical activity on study. Some patients may optionally participate in an interview on study.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

Non-Interventional Study

Observational

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with primary diagnosis of cancer when 15-39 years old.

You may qualify if:

• Adults (aged 18+ years)
• Primary diagnosis of cancer when 15-39 years-old
• Access to a desktop computer or laptop with reliable internet access
• No gross motor impairments that prohibit ambulation
• Willing to complete study requirements
• English speaking

You may not qualify if:

• Diagnosed with nonmelanoma skin cancer only
• Not diagnosed with cancer in adolescent and young adult (AYA) age range of 15-39 years
• Scheduled travel during the study period that is not indicative of individual's normal schedule

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

RECRUITING

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Diane K. Ehlers, PhD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Melissa Cole

CONTACT

480-574-4052; mailto:ARZENL@mayo.edu

Clinical Trials Referral Office

CONTACT

855-776-0015; mayocliniccancerstudies@mayo.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2025
• First Posted: March 18, 2025
• Study Start: July 1, 2025
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: December 17, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: At time of first publication (as required by journals) until last manuscript is published.
• Access Criteria: If required by journal and case by case upon request to the PI

Locations

US (1)