Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD

NCT07186699 | Recruiting DMC

• 3 other identifiers: 2N-25-7NCI-2025-05477P30CA014089
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 2

Brief Summary

This study will attempt to identify social facilitators and barriers to detection and treatment of non-small cell lung cancer in order to learn how a history of substance abuse or alcohol use impacts care for non-small cell lung cancer.

Conditions

Lung Non-Small Cell Carcinoma

Outcome Measures

Primary Outcomes (1)

• Thematic saturation

  Will use a Danaher framework to approach analyze interview data using NVivo software (NVivo version 11.0, QSR International). Each interview will be analyzed to identify broad themes.

  Up to 3 years

Study Arms (1)

Observational

Patients participate in a semi-structured interview and may participate in a follow-up focus group interview in which preliminary findings are shared and feedback is elicited on study.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

Non-interventional study

Also known as: Non-Interventional Observational Study, Noninterventional (Observational) Study

Observational

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with NSCLC recruited through USC/Norris Comprehensive Cancer Center

You may qualify if:

• \* Adults ≥ 18 years of age
• Histopathologic or cytologic diagnosis of NSCLC
• Received or receiving curative intent treatment (e.g. surgery, radiation therapy, systemic therapy)
• History of alcohol use or substance use disorder (other than tobacco use disorder) within the past 10 years, predating the cancer diagnosis
• Ability to understand and the willingness to sign a written informed consent
• English or Spanish speaking. Due to need to conduct semi-structured interviews which can develop into free-flowing conversations we need both participant and interviewer to be fluent

You may not qualify if:

• Patients with cognitive disability unable to maintain 30-60 minute conversation

Sponsors & Collaborators

• University of Southern California: lead
• National Cancer Institute (NCI): collaborator

Study Sites (2)

Los Angeles General Medical Center

Los Angeles, California, 90033, United States

RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

RECRUITING

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Brooks V Udelsman

  University of Southern California

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 10, 2025
• First Posted: September 22, 2025
• Study Start: September 29, 2025
• Primary Completion (Estimated): September 12, 2027
• Study Completion (Estimated): September 12, 2028
• Last Updated: April 2, 2026

Record last verified: 2026-03

Locations

US (2)