Fractal and Morphometric Analysis of Mandibular Bone in Periodontitis

NCT07209579 | Completed

• 1 other identifier: 1717821
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to evaluate the differences in mandibular bone structure between individuals with periodontitis and healthy controls using panoramic radiographs. Fractal analysis and radiomorphometric indices, such as the mental index (MI) and panoramic mandibular index (PMI), will be applied to assess trabecular and cortical bone. The study population includes patients previously diagnosed and treated for periodontitis and healthy individuals with available panoramic radiographs. By comparing bone quality and microarchitecture between the groups, the study seeks to determine the diagnostic value of panoramic radiographs for detecting periodontal bone changes and to provide insights for early diagnosis and treatment planning in dental practice.

Conditions

Periodontitis; Panoramic Radiography

Keywords

Fractal analysis, Morphometric indices, Panoramic radiography, Mandibular bone, Periodontitis

Outcome Measures

Primary Outcomes (1)

• Difference in fractal dimension values between periodontitis and healthy groups

  Fractal dimension (FD) values of mandibular bone will be measured from panoramic radiographs using ImageJ software and compared between periodontitis patients and healthy controls.

  At baseline

Secondary Outcomes (1)

• Differences in morphometric indices between groups

  At baseline

Study Arms (2)

Periodontitis Group

Individuals diagnosed with periodontitis based on 2017 EFP/AAP classification

Healthy Control Group

Systemically and periodontally healthy individuals

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of adults aged 18 years and older who underwent panoramic radiographic examinations at the Department of Oral and Maxillofacial Radiology, Istanbul University. The case group included patients diagnosed with periodontitis based on clinical and radiographic criteria, while the control group included periodontally and systemically healthy individuals.

You may qualify if:

• Individuals aged 18 or older
• Patients with clinically and radiographically diagnosed periodontitis (case group)
• Periodontally and systemically healthy individuals (control group)

You may not qualify if:

• Individuals younger than 18
• Patients with systemic or syndromic conditions affecting bone structure
• Panoramic radiographs with artifacts or diagnostic errors

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul University Faculty of Dentistry

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant, PhD

Study Record Dates

• First Submitted: September 29, 2025
• First Posted: October 7, 2025
• Study Start: April 15, 2023
• Primary Completion: May 15, 2023
• Study Completion: May 15, 2023
• Last Updated: October 7, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)