Interleukin 20 and Periodontal Tisuue Destruction

NCT06091800 | Completed

• 2 other identifiers: RecepTayyip ErdoganUniversityRecep Tayyip ErdoganUniversity
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction. In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels

Conditions

Periodontitis

Outcome Measures

Primary Outcomes (2)

• concentration of biochemical findings in gingival crevicular fluid (GCF)

  IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF

  june 2022-june 2023

• concentration of biochemical findings in serum

  IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10

  1 year

Secondary Outcomes (2)

• value of periodontal clinical parameters

  1 year

• value of periodontal clinical parameters were measured in mm

  1 year

Study Arms (2)

control group (periodontally healthy)

no attachment loss, probing pocket depth ≤ 3 mm, minimal bleeding on probing ≤ 10%, and no radiographic bone loss

Other: biochemical analysis

periodontitis group

interdental clinical attachment level ≥ 5 mm, probing pocket depth ≥ 6 mm, radiographic bone loss extending to the middle or apical thirds of the root, mid-crest defect, and a history of ≤4 teeth loss of periodontal origin

Other: biochemical analysis

Interventions

biochemical analysis OTHER

GCF and serum samples were collected from the participants for biochemical analysis.

control group (periodontally healthy); periodontitis group

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment

You may not qualify if:

• smoking, using antibiotics or systemic corticosteroids within the previous three months, pregnant, receiving periodontal therapy within the previous six months

Sponsors & Collaborators

• Recep Tayyip Erdogan University: lead

Study Sites (1)

Recep Tayyip Erdogan University

Rize, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITH DNA

serum and gingival crevicular fluid

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Yemenoglu

  Recep Tayyip Erdogan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: October 11, 2023
• First Posted: October 19, 2023
• Study Start: June 6, 2022
• Primary Completion: March 6, 2023
• Study Completion: June 6, 2023
• Last Updated: October 19, 2023

Record last verified: 2023-10

Locations

TU (1)