IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients

NCT07206732 | Not Yet Recruiting

• 1 other identifier: IVC-CVP-ShockED-2025
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare ultrasound-guided inferior vena cava (IVC) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in shock patients in the emergency department. The primary objective is to evaluate the diagnostic accuracy and clinical utility of IVC collapsibility index compared to CVP values in both early and post-resuscitation phases. The study will prospectively enroll shock patients, collect demographic and clinical data, and analyze the correlation between IVC and CVP measurements to determine their role in guiding fluid resuscitation and hemodynamic management.

Conditions

Shock; Hypovolemia; Circulatory Failure

Keywords

Shock; Hypovolemia; Emergency department; Central venous pressure; Fliud resuscitation; Ultrasound guided IVC

Outcome Measures

Primary Outcomes (1)

• Correlation Between IVC Collapsibility Index and Central Venous Pressure

  The primary outcome is to assess the diagnostic agreement between ultrasound-guided inferior vena cava (IVC) collapsibility index and central venous pressure (CVP) values in detecting hypovolemia among shock patients in the emergency department. Measurements will be collected at two time points: during early presentation and after initial fluid resuscitation. The outcome will be evaluated by analyzing correlation coefficients, sensitivity, and specificity of IVC measurements compared with CVP

  IVC assessment will be performed at presentation and 1 hour post-resuscitation, while CVP will be monitored continuously during the first 6 hours after ED admission.

Interventions

Ultrasound-Guided Inferior Vena Cava Assessment DEVICE

This intervention involves bedside ultrasound measurement of the inferior vena cava (IVC) diameter and calculation of the IVC collapsibility/distensibility index. Assessments will be performed both at initial presentation and after fluid resuscitation in shock patients. The procedure is non-invasive, rapid, and performed according to standardized emergency ultrasound protocols, distinguishing it from invasive monitoring methods.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include adult patients aged 18-65 years presenting with shock to the emergency department and requiring volume status assessment through both IVC ultrasound and central venous pressure monitoring.

You may qualify if:

• Adult patients aged ≥18 years. 2.Both male and female patients will be included in the study. 3. Presentation to the Emergency Department with clinical evidence of shock, defined by: Hypotension (systolic blood pressure \<90 mmHg or mean arterial pressure \<65 mmHg).
• Evidence of tissue hypoperfusion (e.g., altered mental status, cold extremities, or oliguria).
• Elevated serum lactate (\>2 mmol/L). 4. Shock attributed to hypovolemic, septic, or hemorrhagic etiologies. 5. Patients requiring fluid resuscitation and hemodynamic monitoring.

You may not qualify if:

• Patients younger than 18 years. 2. Pregnancy. 3.Cardiogenic or obstructive shock (e.g., cardiac tamponade, massive pulmonary embolism, or tension pneumothorax).
• Known inferior vena cava (IVC) anomalies (e.g., congenital absence, thrombosis).
• \. Increased intra-abdominal pressure or severe ascites. 6. Morbid obesity (BMI ≥40 kg/m²) or any condition interfering with adequate IVC ultrasound visualization.
• \. Prior central venous catheterization performed before Emergency Department arrival.
• \. Congestive heart failure (CHF) with left ventricular ejection fraction (LVEF \<40%) or pulmonary hypertension.
• \. Refusal of the patient or legal guardian to participate in the study.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Emeregency medicine department ,Assiut University

Asyut, Sahel Selim, Egypt

Location

MeSH Terms

Conditions

Shock; Hypovolemia; Emergencies

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Study Officials

• Alaa M Attia, Professor of Anathesia and ICU

  Assit University

  PRINCIPAL INVESTIGATOR

• Ahmed M Mandor, Consultant of Anathesia ICU

  Assiut University

  STUDY DIRECTOR

• Walaa M Adel, Lecture of emergency medicine

  Seuz canal University

  STUDY DIRECTOR

Central Study Contacts

Mahmoud Ahmed Mohamed Abd Elgwad, M.B.B.Ch

CONTACT

+01280752523; mahmoudataay12@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator at Emergency Medicine department Assiut University

Study Record Dates

• First Submitted: September 26, 2025
• First Posted: October 3, 2025
• Study Start: December 15, 2025
• Primary Completion (Estimated): November 15, 2026
• Study Completion (Estimated): December 15, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)