Prioritisation of Acute Appendicitis Using Appendistat Score

NCT07197489 | Completed DMC

• 1 other identifier: 206417
• Study Type: observational
• Target: 592
• Locations: 1 country
• Sites: 2

Brief Summary

Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment. Prioritization of patients at risk of developing complicated appendicitis is essential for improving outcomes. The aim of this study was to assess the predictive value and clinical utility of the Appendistat (APS) scoring system as a triaging tool to prioritize patients with a high risk of developing complicated appendicitis. Methods This was a chart review, cross-sectional observational diagnostic study, with a single-gate retrospective design, including 592 patients who underwent appendicectomy. Based on final histological diagnosis, patients were categorized as normal, acute uncomplicated appendicitis (AUA), or acute complicated appendicitis (ACA). The predictive value matrix of the APS score for identifying patients with a histological diagnosis of complicated appendicitis was calculated.

Conditions

Acute Appendicitis; Acute Appendicitis With Rupture

Keywords

Appendicitis; Appendistat score; Triage tool; risk stratification; complicated appendicitis; Emergency surgery

Outcome Measures

Primary Outcomes (1)

• Area under the receiver operating characteristic (ROC) curve (AUC) of the Appendistat Score (APS) for predicting histologically confirmed complicated appendicitis

  Diagnostic accuracy of APS assessed by calculating the AUC of the ROC curve for discriminating complicated appendicitis from

  At time of hospital admission (within 24 hours of presentation)

Secondary Outcomes (2)

• Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the Appendistat Score (APS) for detecting complicated appendicitis

  At time of hospital admission (within 24 hours of presentation)

• Mean Appendistat Score (APS) values in patients with histologically confirmed uncomplicated vs. complicated appendicitis

  At time of hospital admission (within 24 hours of presentation)

Study Arms (1)

Right iliac fossa pain

Post operative classification into: acute uncomplicated appendicitis; acute complicated appendicitis; and normal appendix

Eligibility Criteria

• Age: 16 Years - 95 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients presenting to the surgical assessment unit with acute right iliac fossa pain

You may qualify if:

• Patients aged 16-years and above, with a conclusive histological report were included.

You may not qualify if:

• hysterectomy, and those without a conclusive pathology report were excluded

Sponsors & Collaborators

• University College, London: lead

Study Sites (2)

University College London

London, OX3 8PF, United Kingdom

Location

Oxford University Hospitals NHS Trust

Oxford, United Kingdom

Location

Related Publications (1)

• Lerea KM, Livingston JN. The different receptor species of liver have similar complex insulin binding properties. Biochem Biophys Res Commun. 1983 Aug 12;114(3):1042-7. doi: 10.1016/0006-291x(83)90667-8.

  PMID: 6351858 BACKGROUND

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 5 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2025
• First Posted: September 29, 2025
• Study Start: January 6, 2024
• Primary Completion: December 2, 2024
• Study Completion: August 2, 2025
• Last Updated: September 29, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (2)