MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
observational
APPENDICITIS DURING THE COVID-19 PANDEMIC: TO OPERATE OR NOT TO OPERATE, THAT IS THE QUESTION: COHORT STUDY FROM A TERTIARY CENTRE
1 other identifier
observational
207
1 country
1
Brief Summary
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA during the pandemic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 5, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
October 6, 2020
CompletedFirst Submitted
Initial submission to the registry
November 2, 2020
CompletedFirst Posted
Study publicly available on registry
November 4, 2020
CompletedNovember 4, 2020
November 1, 2020
8 months
November 2, 2020
November 2, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Mortality
Death secondary to acute appendicitis
within 90 days of a patient's initial presentation
Failure of primary proposed treatment
failure of conservative management and need to undergo surgery
within 90 days of a patient's initial presentation
Secondary Outcomes (4)
length of stay
within 90 days of a patient's initial presentation
Re-attendance
within 90 days of a patient's initial presentation
Imaging
within 90 days of a patient's initial presentation
Intra-operative findings during surgery
within 90 days of a patient's initial presentation
Study Arms (2)
pre-COVID cohort
Patients recruited from 1st November 2019 to 9th March 2020
COVID cohort
Patients recruited from 10th March 2020 to 5th July 2020
Interventions
Laparoscopic/open appendicectomy versus conservative management with antibiotic therapy with or without image-guided drainage of appendicular abscess/collection
Eligibility Criteria
Patients included in this study were all adults (≥16 years) with a diagnosis of acute appendicitis made clinically and/or radiologically in our hospital. Patients presented sequentially to the emergency department, and subsequently were referred to the emergency surgical service for further management.
You may qualify if:
- Patients aged 16 years old and above
- Confirmed diagnosis of acute appendicitis
You may not qualify if:
- Patients aged less than 16 years old
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Addenbrooke's University Hospital
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Mr
Study Record Dates
First Submitted
November 2, 2020
First Posted
November 4, 2020
Study Start
November 1, 2019
Primary Completion
July 5, 2020
Study Completion
October 6, 2020
Last Updated
November 4, 2020
Record last verified: 2020-11
Data Sharing
- IPD Sharing
- Will not share
As individual participant data contain private confidential data, this data will not be shared or made available publicly however the primary would be to answer or clarify any relevant queries.