Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis
Development and Validation of an Individualized Nomogram to Differentiate Uncomplicated From Complicated Acute Appendicitis in Adults: a Multicenter Study
1 other identifier
observational
250
1 country
1
Brief Summary
Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. The study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 3, 2023
CompletedFirst Submitted
Initial submission to the registry
April 25, 2023
CompletedFirst Posted
Study publicly available on registry
May 6, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 3, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 3, 2023
CompletedMay 6, 2023
May 1, 2023
5 months
April 25, 2023
May 4, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Accuracy of clinical-radiomic model for differentiating complicated from uncomplicated appendicitis
ROC curve will be plotted and the area under ROC curve will be compared
January 2021 to December 2022
Study Arms (3)
Training cohort
Model construction based on training cohort
Validation cohort 1
Model validation in an independent validation cohort 1
Validation cohort 2
Model validation in an independent validation cohort 2
Interventions
Eligibility Criteria
All adults with pathologically diagnosed as acute appendicitis after appendectomy
You may qualify if:
- Pathologically diagnosed as acute appendicitis after appendectomy between January 2021 and December 2022.
You may not qualify if:
- age less than 18 years (no upper age limit);
- without CT examination within a week before surgery;
- difficult to outline the contours of the appendix due to inflammatory exudate;
- lack of clinical information.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Kecheng Zhanglead
Study Sites (1)
Chinese PLA General Hospital First Medical Center
Beijing, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kecheng Zhang
Senior Department of General Surgery, Chinese PLA General Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Department of General Surgery, Chinese PLA General Hospital First Medical Center
Study Record Dates
First Submitted
April 25, 2023
First Posted
May 6, 2023
Study Start
January 3, 2023
Primary Completion
June 3, 2023
Study Completion
December 3, 2023
Last Updated
May 6, 2023
Record last verified: 2023-05