Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score

NCT04730752 | Completed

• 1 other identifier: 2021/07
• Study Type: observational
• Target: 174
• Locations: 1 country
• Sites: 1

Brief Summary

Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases. Despite the advances and widespread use of imaging modalities, still negative laparotomies are performed with the initial diagnosis of acute appendicitis. Several scoring systems are developed by using various clinical and laboratory parameters in order to improve the diagnostic accuracy and prevent unnecessary laparotomies.

Conditions

Acute Appendicitis; Acute Appendicitis With Rupture

Outcome Measures

Primary Outcomes (2)

• Exclude acute appendicitis

  The ability of the scoring systems in detecting patients without acute appendicitis presenting with right lower quadrant pain to emergency service

  6 months

• Predicting the severity of acute appendicitis

  The ability of scoring systems in predicting the rate of perforation in patients with acute appendicitis

  6 months

Study Arms (1)

Right Low Quadrant Pain

AIR and AAS scores will be calculated for the patients with right low quadrant pain in emergency service.

Diagnostic Test: Appendicitis Inflammatory Response; Diagnostic Test: Adult Appendicitis Score

Interventions

Appendicitis Inflammatory Response DIAGNOSTIC_TEST

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Right Low Quadrant Pain

Adult Appendicitis Score DIAGNOSTIC_TEST

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Right Low Quadrant Pain

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients between 18-65 years old, presenting to ER with right lower quadrant pain.

You may qualify if:

• Presenting to ER with right lower quadrant pain
• Patients between 18-65 years old.

You may not qualify if:

• Patients receiving immun-suppressive therapy
• Patients with diagnosed malignancy
• Presence of mental retardation
• Patients with previous right hemicolectomy
• Patients with previous appendectomy
• Pregnant women

Sponsors & Collaborators

• Nigde Omer Halisdemir University: lead

Study Sites (1)

Niğde Ömer Halisdemir University Training and Research Hospital

Niğde, 51100, Turkey (Türkiye)

Location

Related Publications (5)

• Ohle R, O'Reilly F, O'Brien KK, Fahey T, Dimitrov BD. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med. 2011 Dec 28;9:139. doi: 10.1186/1741-7015-9-139.

  PMID: 22204638 BACKGROUND

• Huckins DS, Copeland K. Diagnostic accuracy of combined WBC, ANC and CRP in adult emergency department patients suspected of acute appendicitis. Am J Emerg Med. 2021 Jun;44:401-406. doi: 10.1016/j.ajem.2020.04.086. Epub 2020 Apr 29.

  PMID: 32482481 BACKGROUND

• Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, Boermeester M, Sartelli M, Coccolini F, Tarasconi A, De' Angelis N, Weber DG, Tolonen M, Birindelli A, Biffl W, Moore EE, Kelly M, Soreide K, Kashuk J, Ten Broek R, Gomes CA, Sugrue M, Davies RJ, Damaskos D, Leppaniemi A, Kirkpatrick A, Peitzman AB, Fraga GP, Maier RV, Coimbra R, Chiarugi M, Sganga G, Pisanu A, De' Angelis GL, Tan E, Van Goor H, Pata F, Di Carlo I, Chiara O, Litvin A, Campanile FC, Sakakushev B, Tomadze G, Demetrashvili Z, Latifi R, Abu-Zidan F, Romeo O, Segovia-Lohse H, Baiocchi G, Costa D, Rizoli S, Balogh ZJ, Bendinelli C, Scalea T, Ivatury R, Velmahos G, Andersson R, Kluger Y, Ansaloni L, Catena F. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27. doi: 10.1186/s13017-020-00306-3.

  PMID: 32295644 BACKGROUND

• Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008 Aug;32(8):1843-9. doi: 10.1007/s00268-008-9649-y.

  PMID: 18553045 BACKGROUND

• Sammalkorpi HE, Mentula P, Leppaniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014 Jun 26;14:114. doi: 10.1186/1471-230X-14-114.

  PMID: 24970111 BACKGROUND

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 24, 2021
• First Posted: January 29, 2021
• Study Start: March 1, 2021
• Primary Completion: May 25, 2021
• Study Completion: May 25, 2021
• Last Updated: May 27, 2021

Record last verified: 2021-05

Locations

TU (1)