Sexual Dysfunction in Women With Multiple Sclerosis (MS)

NCT07193823 | Recruiting

• 1 other identifier: 24-5.1T/1
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

Sexual dysfunction in women with multiple sclerosis (MS) is an important yet often overlooked problem. The primary objective of this study is to investigate the prevalence of sexual dysfunction in female patients diagnosed with MS. The secondary objective is to evaluate the relationship between sexual dysfunction and fatigue, depression, anxiety, overactive bladder symptoms, and cognitive dysfunction. For this purpose, the following validated instruments will be used: the Female Sexual Function Index (FSFI) to assess sexual dysfunction, the Brief International Cognitive Assessment for MS (BICAMS) to evaluate cognitive function, the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety, the Fatigue Severity Scale (FSS) to measure fatigue, and the Overactive Bladder Questionnaire (OAB-V8) to evaluate overactive bladder symptoms.

Conditions

Multiple Sclerosis; Multiple Sclerosis (MS) - Relapsing-remitting; Fatigue in Multiple Sclerosis; Sexual Disfunction; Cognitive Dysfunction; Depression; Anxiety; Overactive Bladder; Fatigue

Keywords

multiple sclerosis; sexual dysfunction; cognitive dysfunction; depression; anxiety; overactive bladder; fatigue

Outcome Measures

Primary Outcomes (1)

• Prevalence of sexual dysfunction in female patients with multiple sclerosis

  At enrollment (Baseline, cross-sectional assessment)

Secondary Outcomes (1)

• Association between sexual dysfunction and cognitive dysfunction, fatigue, depression, anxiety, and overactive bladder symptoms

  At enrollment (Baseline, cross-sectional assessment)

Eligibility Criteria

• Age: 25 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female patients with MS under follow-up at the Department of Neurology, Ege University.

You may qualify if:

• Female patients aged 25-50 years
• Literate and able to comprehend written and spoken instructions
• Diagnosed with relapsing-remitting form of multiple sclerosis
• Having a continuous/regular sexual partner
• Expanded Disability Status Scale (EDSS) score ≤ 5
• At least 3 months since the last relapse
• Sexually active within the past 3 months
• Spasticity level \< grade 2 according to the Modified Ashworth Scale

You may not qualify if:

• Pregnancy
• Illiteracy or inability to understand spoken or written instructions
• Absence of a continuous/regular sexual partner
• Expanded Disability Status Scale (EDSS) score \> 5
• Not sexually active within the past 3 months
• Spasticity level ≥ grade 2 according to the Modified Ashworth Scale

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Faculty of Medicine, Department of Neurology

Izmir, Bornova, 35100, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Cognitive Dysfunction; Depression; Anxiety Disorders; Urinary Bladder, Overactive; Fatigue; Sexual Dysfunction, Physiological

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavioral Symptoms; Behavior; Urinary Bladder Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Genital Diseases

Study Officials

• Yesim Akkoc, M.D., Prof

  Ege University Faculty of Medicine, Department of Physical Medicine and Rehabilitation

  STUDY DIRECTOR

Central Study Contacts

Merve Dokumaci, Resident doctor

CONTACT

+905435088428; dokumacimerve@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Doctor, Department of Physical Medicine and Rehabilitation

Study Record Dates

• First Submitted: September 15, 2025
• First Posted: September 26, 2025
• Study Start: July 16, 2024
• Primary Completion: October 1, 2025
• Study Completion: November 1, 2025
• Last Updated: September 26, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)