Effect of Training With Wireless Lightning Reaction Systems on Cognitive Functions in Individuals With Multiple Sclerosis

NCT06874764 | Enrolling By Invitation

• 1 other identifier: 25-5/4
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

When the literature is examined, balance disorders, walking disorders and cognitive problems are frequently observed in Multiple Sclerosis(MS) patients. Using technologically supported equipment such as reaction systems, cognitive function measurements have been successfully performed in the elderly, and improvements in reaction times have been detected in athletes when used for training purposes. The primary aim of the study is to provide improvement in agility and cognitive functions in patients using a technology-supported reaction device. In addition, it aims to improve balance function assessed with static posturography and gait parameters assessed with gait analysis by increasing sensory input and shortening reaction time. As a result of the agility and cognitive training performed, we aim to provide improvement in MS-related quality of life and decrease in disability.

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis; Cognitive; Virtual reality; Agility; Training; Gait

Outcome Measures

Primary Outcomes (1)

• Cognitive Functions

  the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is a battery with demonstrated validity and reliability in Turkish, consisting of the California Verbal Learning Test II (CVLT II), Symbol Digit Modalities Test (SDMT) and Brief Visuospatial Memory Test-Revised (BVMTR) subscales, used to assess cognitive status in MS patients SDMT: There is no lower or upper limit for scoring. A higher number of correct answers (higher scores) is associated with better results. CVLTII:The upper limit for scoring is 80. A higher number of correct answers (higher scores) is associated with better results. BVMTR:The score range is 0-12. Higher scores are associated with better outcomes.

  8th week

Secondary Outcomes (14)

• Balance assessment

  8th week

• Anxiety and Depression Status

  8th week

• Fatigue Assessment

  8th week

• MS Quality of Life

  8th week

• Static Posture Assessment(Static Balance)

  8th week

Study Arms (2)

Training Group

EXPERIMENTAL

The intervention group will be trained with a difficulty appropriate to their individual levels for 2 months using the reaction system 2 days a week to improve agility and cognitive functions, and if the participant can easily perform the relevant training, the difficulty will be increased by one level. Agility training aims to reach the light side sensor with the hand in order and to do this within the specified time, and aims to speed up the participant's reaction time in the foreground. Cognitive training consists of different trainings such as finding the different image illuminated in 8 sensors, finding two identical signs, remembering the order in which the sensors light up, and touching the sensors in that order. These trainings aim to increase the participant's quick thinking and decision making, and to improve attention, visual memory, visual processing speed, and cognitive functions. Each training session will last approximately 30 minutes.

Other: Wireless Lighting Reaction System Training(Agility plus Cognitive)

Control Group

NO INTERVENTION

The control group will not receive any intervention. They will be asked to continue their normal lives.

Interventions

Wireless Lighting Reaction System Training(Agility plus Cognitive) OTHER

Agility training and Cognitive trainings(cognitive trainings ready within the device: Eye for detail, Hawk eye, Juggle Factor)

Training Group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Being between the ages of 18-55
• Having a definite MS diagnosis according to the 2017 McDonald criteria.
• EDSS score of 4 or below
• Being able to communicate (speaking and understanding Turkish, no speech disorders)

You may not qualify if:

• Regular exercise in the last 6 months
• Having an MS attack in the last month
• Having an MS attack during the study period
• Presence of additional accompanying neurological diseases
• Use of dalfampridine
• Use of antipsychotic and psychostimulant drugs
• Drug and alcohol addiction
• Pregnancy, breastfeeding
• No chronic systemic disease preventing exercise
• Patients who cannot reach the targeted exercise level

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Sport Medicine Clinic

Izmir, Bornova, Turkey (Türkiye)

Location

Related Publications (33)

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MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 3, 2025
• First Posted: March 13, 2025
• Study Start: January 1, 2026
• Primary Completion: May 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: January 9, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)