NCT07193303

Brief Summary

Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms such as bradykinesia, resting tremor, and/or rigidity. Among the motor deficits frequently observed in PD, patients are known to frequently report difficulties with manual dexterity. Many upper extremity and manual dexterity deficits are present in PD. Motor imagery (MI) is the imaginal execution of motor activities or the activation of specific muscles in the absence of any explicit feedback. This area of rehabilitation has been shown to be effective in improving and developing motor skills in many neurological conditions where patients exhibit motor recognition and execution impairments. MI can be applied at all stages of recovery from PD, is highly effective in movement-related pathologies, and can be performed independently.There is sufficient evidence that MI improves motor performance and learning in individuals with neurological disorders such as multiple sclerosis, stroke, and spinal cord injury. The study was designed to investigate the immediate effects of mental imagery, which is thought to be effective in controlling difficulties in planning and initiating movements in PD, on upper extremity skills. Therefore, the aim of this study was to determine the effect of mental imagery on upper extremity skills in PD.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

September 12, 2025

Completed
13 days until next milestone

First Posted

Study publicly available on registry

September 25, 2025

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 30, 2026

Completed
Last Updated

December 19, 2025

Status Verified

December 1, 2025

Enrollment Period

6 months

First QC Date

September 12, 2025

Last Update Submit

December 18, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • The Nine-Hole Peg Test (9PPT) with Mental Chronometry

    Mental Chronometry: Mental chronometry is a method that measures imagery time, considered more objective than questionnaires in the assessment of MI. It examines the time difference between the actual physical execution of a movement and the mental image of the same movement. The Nine-Hole Peg Test (9PPT) is frequently used in the literature, although its validity and reliability as a mental chronometry test are lacking. In this task, the participant is required to remove nine pegs from the board to which they are fixed as quickly as possible and place them in a container on the board. The pegs used in the test (8 mm in diameter, 3 cm long) can be made of wood or plastic. The board (23 cm long, 10 cm wide, and 2 cm high) has a section at one end where the pegs are fixed (arranged in a 3x3 matrix) and a container-shaped space on the side for the pegs to be placed. Participants perform the test on both upper extremities. Before the test, all participants are given the opportunity to ho

    first day of the assesment

Secondary Outcomes (7)

  • sosyodemographic form

    first day of the assesment

  • Modified Hoehn & Yahr (m-HY) scale

    first day of the assesment

  • Unified Parkinson's Disease Rating Scale (UPDRS)

    first day of the asessment

  • Mini Mental State Examination (MMSE)

    first day of the assessment

  • Muscle Strength Measurement

    first day of the assesment

  • +2 more secondary outcomes

Study Arms (2)

1/study group

EXPERIMENTAL

Upper extremity skill tests will be performed on individuals diagnosed with idiopathic Parkinson's disease and recorded with a mental stopwatch using mental imagery.

Other: mental imagination

2/control group

NO INTERVENTION

Upper extremity skill tests will be performed on individuals diagnosed with idiopathic Parkinson's disease.

Interventions

The Nine-Hole Peg Test (9 DPT) will be performed with a mental chronometer.the duration between actually physically performing the movement and mentally imagining the same movement will be recorded.

1/study group

Eligibility Criteria

Age40 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy individuals aged 40-75 years, diagnosed with idiopathic PD according to the UK Parkinson's Disease Association Brain Bank criteria by a specialist neurologist, with a Modified Hoehn \& Yahr (m-HY) scale stage ≤4, and with a Mini Mental State Examination score of ≥24 for those with training and ≥18 for those without training, and with no known disease, volunteered to participate in the study.
  • PD individuals with no other known neurological and/or systemic disease
  • PD individuals without any upper extremity contractures

You may not qualify if:

  • Individuals with diagnosed and/or treated psychiatric illnesses who are considered unable to complete the tests.
  • Individuals who is taking neuroleptic medications or antidepressants.
  • Individuals with orthopedic conditions that interfere with manual dexterity tests, such as severe dyskinesia, carpal tunnel syndrome, tendon injuries, or finger amputations; rheumatological conditions such as rheumatoid arthritis and osteoarthritis; and individuals with any neurological condition other than PD.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kahramanmaraş Sütçü imam University

Kahramanmaraş, Onikişubat, 46100, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Officials

  • hatice adıgüzel tat, Associate Professor

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR
  • Asiya Uzun, Asisstant Prof

    Kahramanmaras Sutcu Imam University

    PRINCIPAL INVESTIGATOR
  • Yusuf Şinasi Kırmacı, Asisstant Prof

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR
  • Abdulkadir Ertürk, Msc

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR
  • Tuğçe Simay Özbay, Msc

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR
  • Buket Tuğan Yıldız, Associate Professor

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR
  • Deniz Tuncel, Proffessor

    Kahramanmaras Sutcu Imam University

    STUDY CHAIR

Central Study Contacts

Hatice adıgüzel tat, Associate Proffessor

CONTACT

hatice Adiguzel tat, Associate Proffessor

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Profesor

Study Record Dates

First Submitted

September 12, 2025

First Posted

September 25, 2025

Study Start

July 1, 2025

Primary Completion

December 31, 2025

Study Completion

January 30, 2026

Last Updated

December 19, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations