Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients

NCT07188272 | Completed

• 1 other identifier: September 2025
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients

Conditions

Hypertension; Arterial Stiffness

Outcome Measures

Primary Outcomes (1)

• Pulse Wave Velocity

  normal level 60-100 per minutes

  each week

Study Arms (2)

DASH diet group

EXPERIMENTAL

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT) combined with DASH diet.

Dietary Supplement: DASH diet

Comparator group

ACTIVE COMPARATOR

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT)

Procedure: High Intensity Interval Training

Interventions

DASH diet DIETARY_SUPPLEMENT

Eating vegetables, fruits, and whole grains Including fat-free or low-fat dairy products, fish, poultry, beans, nuts, and vegetable oils Limiting foods that are high in saturated fat, such as fatty meats, full-fat dairy products, and tropical oils such as coconut, palm kernel, and palm oils Limiting sugar-sweetened beverages and sweets

DASH diet group

High Intensity Interval Training PROCEDURE

High Intensity Interval Training

Comparator group

Eligibility Criteria

• Age: 35 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Their age\< 35 up to 50 years old
• Both sexes.
• Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
• Hemodynamic stable. Able to provide informed consent

You may not qualify if:

• Uncontrolled hypertension.
• Severe HTN \<180/110 mmhg
• Renal dysfunction
• Unstable cardiac conditions
• Severe pulmonary disease that limit exercise
• Impaired cognition
• Musculoskeletal problems that made it difficult to do exercise

Sponsors & Collaborators

• Deraya University: lead

Study Sites (1)

Waleed Mohamed Abdelmohsen Abdelsalalm

Minya, Egypt

Location

MeSH Terms

Conditions

Hypertension

Interventions

Dietary Approaches To Stop Hypertension; High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 15, 2025
• First Posted: September 23, 2025
• Study Start: July 10, 2025
• Primary Completion: December 10, 2025
• Study Completion: January 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

EG (1)