Effects of Combined High Intensity Interval Training and Resistance Training

NCT06845436 | Recruiting

• 1 other identifier: SCBR-430/2025
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Hypertension has long been considered as a major risk factor for cardiovascular disease representing a high public health concern. Objectives: the purpose of this study is to evaluate the effects of combined HIIT and resistance training on body composition, blood pressure, and cardiorespiratory fitness in obese hypertensive men. Methods: This study will make use of sixty obese hypertensive men aged 40 to 60 years. All participants meeting the eligibility criteria will be assigned to one of three groups; combined HIIT and resistance group, HIIT only group or control group. Combined exercise group subjects will undergo weekly three sessions of both HIIT and resistance training for sixteen weeks. The HIIT session will involve four four-minute high-intensity intervals with an intensity of at 80-95% of the HRmax interspersed with two-minute active recovery intervals with intensity of 40% to 60% of the HRmax. The resistance training session will be composed of eight exercises perform 3 sets of 8-12 repetitions with an intensity of 80% of the subject's estimated 1-RM. The HIIT only group perform 12 weeks of HIIT only. The control group subjects will be instructed not to change their usual daily physical activities routine and instructed to abstain from practicing any exercise regimens during the 12-week study period. Body composition measures, blood pressure and VO2peak will be assessed at baseline and at the end of the study period. Results: All the outcome variables will be assessed at baseline and 12 weeks following the treatment period.

Conditions

Hypertension

Keywords

hypertension.; obesity; High Intensity Interval Training; resistance training; blood pressure

Outcome Measures

Primary Outcomes (4)

• blood pressure in mmhg

  12 weeks

• peak oxygen consumption in ml/kg/min

  12 weeks

• body weight in Kg

  12 weeks

• body mass index in kg/m2

  12 weeks

Study Arms (2)

study group

EXPERIMENTAL

Combined exercise group subjects will undergo weekly three sessions of both HIIT and resistance training for sixteen weeks. The HIIT session will involve four four-minute high-intensity intervals with an intensity of at 80-95% of the HRmax interspersed with two-minute active recovery intervals with intensity of 40% to 60% of the HRmax. The resistance training session will be composed of eight exercises perform 3 sets of 8-12 repetitions with an intensity of 80% of the subject's estimated 1-RM. The HIIT only group perform 12 weeks of HIIT only.

Behavioral: Exercise

control group

OTHER

The control group subjects will be instructed not to change their usual daily physical activities routine and instructed to abstain from practicing any exercise regimens during the 12-week study period.

Other: routine physical activity

Interventions

Exercise BEHAVIORAL

Combined exercise group subjects will undergo weekly three sessions of both HIIT and resistance training for sixteen weeks. The HIIT session will involve four four-minute high-intensity intervals with an intensity of at 80-95% of the HRmax interspersed with two-minute active recovery intervals with intensity of 40% to 60% of the HRmax.

study group

routine physical activity OTHER

The control group subjects will be instructed not to change their usual daily physical activities routine and instructed to abstain from practicing any exercise regimens during the 12-week study period.

control group

Eligibility Criteria

• Age: 40 Years - 60 Years
• Gender Eligibility Details: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• men aged between 40 and 60 years old,
• have been diagnosed with clinical stage 1 or 2 hypertension,
• being obese with body mass index more than 30 kg/m2
• physically inactive

You may not qualify if:

• musculoskeletal problems that may limit their ability to participate in resistance or HIIT programs
• diabetes mellitus
• a history of respiratory or chronic heart disease

Sponsors & Collaborators

• Prince Sattam Bin Abdulaziz University: lead

Study Sites (1)

Prince Sattam bin Abdulaziz University

Riyadh, Alkharj, 16278, Saudi Arabia

RECRUITING

MeSH Terms

Conditions

Hypertension; Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Ahmed S Ahmed, PhD

CONTACT

000966564347031; a.aseil@psau.edu.sa

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: February 20, 2025
• First Posted: February 25, 2025
• Study Start: April 1, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: June 4, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)