Acute Effect of Individual Variants of Agonist-antagonist and Traditional Agonistic Resistance Training on Cardiovascular Parameters

NCT06047678 | Active Not Recruiting DMC

• 1 other identifier: CharlesUCRFTVS
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 2

Brief Summary

Prevention and non pharmacological treatment of prehypertension and hypertension stage 1 The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in individuals with normotension and hypertension. What does the study involve?

1. 1.Cardiovascular parameters
2. 2.Body composition
3. 3.Blood tests for heart disease
4. 4.Training intervention
5. 5.Agonistic RT - upper body
6. 6.Agonistic RT - lower body
7. 7.Agonist-Antagonist - upper body
8. 8.Agonist-Antagonist - lower body B. Aerobic training: 60% SF max, 4 x 10 min, 2 min rest between sets
9. 9.Intraabdominal wall tension activity
10. 10.The Borg rating of perceived exertion
11. 11.Handgrip testing
12. 12.Repetition testing (RM)

Conditions

Arterial Stiffness; Hypertension; Cardiovascular Diseases

Keywords

resistance training; arterial stiffness; hypertension; cardiovascular health

Outcome Measures

Primary Outcomes (2)

• Arterial stiffness - Pulse wave velocity

  Specifically, Aortic pulse wave velocity will be measured. The norm is up to 9 m/s, values above 9 m/s indicate impaired arterial stiffness. Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death. Decreased compliance of the central vasculature alters arterial pressure and flow dynamics and impacts cardiac performance and coronary perfusion. It is measured by Arteriograph (TensioMed, Budapest, Hungary).

  The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours.

• Blood pressure

  Measurement of changes in blood pressure level. Increase in systolic and diastolic blood pressure (mm Hg) during resistance training for agonist-antagonist and traditional agonist resistance training. Blood pressure ranges: Normal: less than 120 systolic and 80 diastolic. Elevated: 120-129 systolic and less than 80 diastolic. Stage 1 hypertension: 130-139 systolic or 80-89 diastolic. Stage 2 hypertension: at least 140 systolic or at least 90 diastolic.Investigators are looking for the safest option of resistance training for individuals with hypertension. It is measured by Arteriograph (TensioMed, Budapest, Hungary).

  The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours.

Secondary Outcomes (16)

• Handgrip strength

  before intervention, one session, it takes 10 minutes, week 1

• The concentration of total cholesterol

  before intervention, one session, it takes 15 minutes, week 1

• Body mass index

  before intervention, one session, it takes 15 minutes, week 1

• Harvard step test

  before intervention, one session, it takes 8 minutes, week 1

• Abdominal wall tension

  two measurements, 2x 60-90 minutes, week 1

Study Arms (2)

Normotension group

EXPERIMENTAL

Participants with normotension Adult: 40 - 63 years old Physically active - no professional sportsman

Behavioral: Cardiovascular fitness

Hypertension Stage 1 group

EXPERIMENTAL

Participants with Hypertension Stage 1 Adult: 40 - 63 years old Physically active - no professional sportsman.

Behavioral: Cardiovascular fitness

Interventions

Cardiovascular fitness BEHAVIORAL

A randomized single-blind controlled trial tested the hypothesis that different variants of resistance training (antagonistic lower and upper body training, agonistic lower and upper body training, and aerobic training) have different effects on blood pressure (systolic and diastolic), aortic pulse wave velocity (PWVao), and augmentation index (Aix) values and compared subjects with normotension and hypertension during and after exercise session.

Hypertension Stage 1 group; Normotension group

Eligibility Criteria

• Age: 40 Years - 63 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• participants with normotension and clinical diagnosis of hypertension (1 stage of hypertension)
• adult: 40 - 63 years old
• physically active
• capable of strength and aerobic training

You may not qualify if:

• fluctuating blood pressure
• type 1 and type 2 diabetes mellitus
• after a myocardial infarction
• after a stroke
• with an infectious disease
• with grade 3 obesity
• hypertension II. - IV. degrees
• suffering from dizziness during exercise

Sponsors & Collaborators

• Charles University, Czech Republic: lead

Study Sites (2)

Pavel Kolar´s Centre of Physical Medicine

Prague, 148 00, Czechia

Location

The Faculty of Physical Education and Sport, Charles University

Prague, 162 52, Czechia

Location

Related Publications (1)

• Jurik R, Stastny P, Kolinger D, Gola A, Vetrovsky T. Blood pressure changes during different methods of resistance training in normotensive and stage 1 hypertensive individuals: a repeated measures cross-sectional study. BMC Sports Sci Med Rehabil. 2025 Mar 14;17(1):49. doi: 10.1186/s13102-025-01097-3.

  PMID: 40087719 DERIVED

MeSH Terms

Conditions

Hypertension; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Comparing two groups 1. Normotensive group 2. Hypertension Stage 1 group

Study Record Dates

• First Submitted: August 31, 2023
• First Posted: September 21, 2023
• Study Start: April 1, 2022
• Primary Completion: August 31, 2023
• Study Completion: December 31, 2024
• Last Updated: February 7, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (2)