Cognitive Fraility and Biomarkers in Older Patients

NCT07184073 | Completed

• 1 other identifier: KA21/124
• Study Type: observational
• Target: 129
• Locations: 1 country
• Sites: 1

Brief Summary

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is:

• Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions?
• Can these biomarkers be used as potential tools for early identification in vulnarable populations?

Conditions

Cognitive Impairment; Frail Older Adults; Orthopaedic Surgery

Keywords

cognitive frailty; neurofilament light chain; cerebrospinal fluid biomarkers; older adult patients; orthopedic surgery

Outcome Measures

Primary Outcomes (1)

• Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?

  p\<0,05 was accepted as statistically significant

  preoperatively and four weeks postoperatively

Study Arms (1)

age 65-74

Behavioral: assessment Mini mental state examination; Behavioral: assessment FRAIL scale; Other: collecting cerebrospinal fluid during regional anesthesia

Interventions

assessment Mini mental state examination BEHAVIORAL

pre operatively four weeks postoperatively

age 65-74

assessment FRAIL scale BEHAVIORAL

pre operatively four weeks postoperatively

age 65-74

collecting cerebrospinal fluid during regional anesthesia OTHER

In the operating room regional anesthesia was administered according to the surgical plan

age 65-74

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients aged 65 years or older who underwent elective major lower extremity orthopedic surgery under regional anesthesia

You may qualify if:

• ASA 1-3 patients
• \>65 age patients

You may not qualify if:

• history of psychiatric or neurological disease
• uncontrolled hypertension
• alchohol dependence
• renal failure
• active liver disease
• cancer-related or emergency surgery
• unwillingness to participate

Sponsors & Collaborators

• Baskent University: lead

Study Sites (1)

Baskent University Ankara Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (1)

• Fang J, Liang H, Chen M, Zhao Y, Wei L. Association of preoperative cognitive frailty with postoperative complications in older patients under general anesthesia: a prospective cohort study. BMC Geriatr. 2024 Oct 19;24(1):851. doi: 10.1186/s12877-024-05431-1.

  PMID: 39427111 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

samples of cerebrospinal fluid

MeSH Terms

Conditions

Cognitive Dysfunction; Charcot-Marie-Tooth disease, Type 1F

Interventions

Mental Status and Dementia Tests

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neuropsychological Tests; Psychological Tests; Behavioral Disciplines and Activities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prof. dr

Study Record Dates

• First Submitted: September 13, 2025
• First Posted: September 19, 2025
• Study Start: June 3, 2021
• Primary Completion: September 4, 2022
• Study Completion: September 4, 2022
• Last Updated: September 19, 2025

Record last verified: 2025-09

Locations

TU (1)