Assessment of Executive Functions After Covid-19

NCT04771624 | Completed

• 1 other identifier: 21022021
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.

Conditions

Covid19; Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Neuropsychological test scores

  Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects

  Up to 90 days

Secondary Outcomes (1)

• Severity of the disease

  Up to 90 days

Study Arms (2)

Patients

Subjects who have been Covid positive by RT-PCR at least 60 days ago and not having any symptoms of Covid-19 at the moment

Healthy

Subjects who do not have any general medical, neurological or psychiatric disorder

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In this study, 50 healthcare personnel diagnosed as Covid-19 by RT-PCR treated at the Department of Infectious Diseases, Gazi Yaşargil Tranining and Research Hospital, Sağlık Bilimleri Üniversitesi, Diyarbakır, have been randomly recorded and followed up for 60 days, and age, sex, education level and professionally matched 50 healthy subjects randomly recruited from the personnel of the same hospital.

You may qualify if:

• Covid-19 patients:
• Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
• Asymptomatic at the moment
• Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection
• Healthy subjects:
• Not having any of Covid-19 symptoms at the testing time point
• Not having any general medical, neurological or psychiatric condition

You may not qualify if:

• Covid-19 patients:
• Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
• Having any symptom of acute phase of Covid-19
• Having any other general medical, neurlogical or psychiatric contidions
• Healthy subjects:
• Having any of Covid-19 symptoms at the testing time point
• Having any general medical, neurological or psychiatric condition

Sponsors & Collaborators

• Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital: lead

Study Sites (1)

Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital

Diyarbakır, 21070, Turkey (Türkiye)

Location

Related Publications (3)

• Wilson BA, Betteridge S, Fish J. Neuropsychological consequences of Covid-19. Neuropsychol Rehabil. 2020 Oct;30(9):1625-1628. doi: 10.1080/09602011.2020.1808483. No abstract available.

  PMID: 32869697 BACKGROUND

• Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020 Oct;129:98-102. doi: 10.1016/j.jpsychires.2020.06.022. Epub 2020 Jun 30.

  PMID: 32912598 BACKGROUND

• Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, Fromson JA, Xu Y, Liu X, Xu H, Zhang T, Lu Y, Chen X, Hu H, Tang Y, Yang S, Zhou H, Wang X, Chen H, Wang Z, Yang Z. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study. Brain Behav Immun. 2020 Aug;88:17-27. doi: 10.1016/j.bbi.2020.05.038. Epub 2020 May 19.

  PMID: 32416290 BACKGROUND

MeSH Terms

Conditions

COVID-19; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Mehmet D Güleken, MD

  Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: February 22, 2021
• First Posted: February 25, 2021
• Study Start: October 30, 2020
• Primary Completion: April 30, 2021
• Study Completion: November 1, 2021
• Last Updated: November 9, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)