Sedation and Postoperative Cognitive Functions

NCT05737459 | Completed

• 1 other identifier: IAERH
• Study Type: observational
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. Patients who were given ketamine and dexmedetomidine for sedation were included in the study. The Mini Mental Status Tests of the patients measured on the first and third days of the operation in the preoperative period were determined from the hospital records and recorded.

Conditions

Cognitive Impairment; Femoral Fractures

Keywords

Cognitive Impairment; Mini mental status test; Hip fractures; Ketamine; dexmedetomidine

Outcome Measures

Primary Outcomes (1)

• Mini-Mental Status Test

  Evaluation of the effect of sedation with ketamine and dexmedetomidine on postoperative cognitive functions by Mini-Mental Status Test

  6 months

Secondary Outcomes (2)

• noninvasive mean arterial pressure

  6 months

• The heart rate

  6 months

Study Arms (2)

Group K

Those who have been administered ketamine for perioperative sedation

Group D

Those who have been administered dexmedetomidine for perioperative sedation.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients sedated with ketamine and dexmedetomidine during spinal anesthesia for hip fracture

You may qualify if:

• Patients over the age of 65 who underwent surgery under spinal anesthesia due to hip fracture
• Volunteered to participate in the study

You may not qualify if:

• Patients who are under the age of 65
• Patients with known histories of dementia
• Patients with Alzheimer's disease
• Patients with central nervous system disease
• Patients who scored 15 or less according to the Mini Mental Status Test (MMSE)
• Patients who underwent surgery under general anesthesia
• Patients who refused to voluntarily participate in the study

Sponsors & Collaborators

• Izmir Ataturk Training and Research Hospital: lead

Study Sites (1)

Izmir Katip Çelebi University Atatürk Training and Research Hospital

Izmir, 35360, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Femoral Fractures; Hip Fractures

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Fractures, Bone; Wounds and Injuries; Leg Injuries; Hip Injuries

Study Officials

• Derya A Yurtlu, M.D.

  Izmir Katip Celebi University Atatürk Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 2, 2023
• First Posted: February 21, 2023
• Study Start: May 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: February 21, 2023

Record last verified: 2023-02

Locations

TU (1)