Echocardiographic Assessment of Pulmonary Hypertension in Obstructive Sleep Apnea

NCT07184060 | Not Yet Recruiting

• 1 other identifier: Pulmonary Hypertension in OSA
• Study Type: observational
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study investigates the association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), focusing on the relationship between OSA severity and pulmonary arterial pressures in adult patients.

Conditions

Obstructive Sleep Apnea (OSA); Pulmonary Hypertension

Keywords

obstructive sleep apnea; pulmonary hypertension

Outcome Measures

Primary Outcomes (1)

• Mean Pulmonary Artery Pressure

  The primary objective is to assess the presence and degree of pulmonary hypertension (measured by echocardiography) in OSA patients.

  baseline

Study Arms (1)

adult patients with confirmed OSA

Eligible participants are 18-65 years old and diagnosed with OSA (AHI ≥ 5 events/hour) confirmed through full-night polysomnographic sleep study. Patients will be stratified into mild (AHI 5-14), moderate (AHI 15-29), and severe OSA (AHI ≥ 30). Exclusion criteria include patients with secondary PH (from cardiac causes, chronic thromboembolic disease, or pulmonary conditions), chronic vasodilator therapy, long-term oxygen therapy, advanced organ failure, neuromuscular or chest wall deformities, obesity hypoventilation syndrome, or malignancy. The expected sample size is 55 patients, ensuring enough statistical power to detect associations. Demographic, clinical, echocardiographic, radiological, and sleep study parameters will be collected for each patient.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Eligible participants are 18-65 years old and diagnosed with OSA (AHI ≥ 5 events/hour) confirmed through full-night polysomnographic sleep study. Patients will be stratified into mild (AHI 5-14), moderate (AHI 15-29), and severe OSA (AHI ≥ 30). Exclusion criteria include patients with secondary PH (from cardiac causes, chronic thromboembolic disease, or pulmonary conditions), chronic vasodilator therapy, long-term oxygen therapy, advanced organ failure, neuromuscular or chest wall deformities, obesity hypoventilation syndrome, or malignancy. The expected sample size is 55 patients, ensuring enough statistical power to detect associations. Demographic, clinical, echocardiographic, radiological, and sleep study parameters will be collected for each patient.

You may qualify if:

• Adults aged 18-65 years
• Diagnosed with obstructive sleep apnea (OSA) by full-night polysomnography
• Apnea-Hypopnea Index (AHI) ≥ 5 events/hour

You may not qualify if:

• Secondary pulmonary hypertension due to:Chronic pulmonary diseases, Left ventricular heart disease and Chronic thromboembolic disorders
• Use of pulmonary vasodilator therapy
• Long-term oxygen therapy (LTOT)
• Respiratory neuromuscular weakness
• Chest wall deformities
• End-organ failure (cardiac, renal, hepatic)
• Malignancy
• Obesity hypoventilation syndrome

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Lung Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident at the of Chest Diseases department

Study Record Dates

• First Submitted: September 13, 2025
• First Posted: September 19, 2025
• Study Start: October 30, 2025
• Primary Completion (Estimated): April 30, 2027
• Study Completion (Estimated): August 30, 2027
• Last Updated: September 19, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share