Pulmonaryhypertension in Copd at Different Levels of Smoking

NCT06031311 | Unknown

• 1 other identifier: Pulmonaryhypertension in copd
• Study Type: observational
• Target: 138
• Locations: 0 countries
• Sites: N/A

Brief Summary

To identify Predictors of pulmonary hypertension in COPD patients and its relation to different levels of smoking

Conditions

Pulmonary Hypertension

Outcome Measures

Primary Outcomes (1)

• Predictors of pulmonary hypertension in COPD patients

  Predict pulmonary hypertension in COPD patients

  1 year

Secondary Outcomes (1)

• Relationship between different levels of smoking and predictors of degree of pulmonary hypertension

  1 year

Interventions

Echocardiography and HRCT DIAGNOSTIC_TEST

Echocardiography:is non invasive and easily accessible tool in the diagnosis of any patient with suspected PH.HRCT: is a non-invasive and easily accessible tool to detect pulmonary hypertension in COPD patients.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Full clinical history including:\[demographic data and clinical symptoms including cough with expectoration ,dyspnea,chest wheeze,…etc\] 2.Full clinical examination. 3.laboratory investigations: Complete blood picture , kidney function test, liver function test,coagulation profile 4.Arterial blood gases \[Pao2, Paco2,Sao2,Hco3, P(A\_a)o2 \] 5.PFTS:will be performed and classified into: Post bronchodilator FEV1/FVC \<0.7 GOLD 1 - mild: FEV1 ≥80% predicted. GOLD 2 - moderate: 50% ≤ FEV1 \<80% predicted. GOLD 3 - severe: 30% ≤ FEV1 \<50% predicted. GOLD 4 - very severe: FEV1 \<30% predicted \[5\] 6.Echocardiography:is non invasive and easily accessible tool in the diagnosis of any patient with suspected PH. ePASP is estimated by calculating Doppler estimated trans tricuspid gradient (TR gradient= 4 x (TR velocity)2) and adding estimated right atrial pressure to it based on the size of the inferior vena cava and collapsibility.\[6\]

You may qualify if:

• All patients admitted to chest department or presented to our outpatient clinic with clinical and functional diagnosis of COPD among both sexes will be included 2.Age \>18 years Old

You may not qualify if:

• Patients under 18 years old. 2.pregnant patients. 3.patients with history hypertension or valvular diseases 4.Cardiomyopathic patient 5.Patients with concomitant obstructive sleep apnea 6.Patients with collagen vascular disease 7.Patients with thrombo-embolic disease 8. Patients with any chronic chest disease other than COPD

Sponsors & Collaborators

• Assiut University: lead

Related Links

• Global Initiative for Chronic Obstructive Lung Disease 2023

MeSH Terms

Conditions

Hypertension, Pulmonary

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Central Study Contacts

Shrouk Mohamed Salah, Resident physician

CONTACT

01150637673; Shrouksalah806@gmail.com

Marwan Nasr Sleem, Lecturer of Chest diseases and

CONTACT

01150637673; faridamarwan2014@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: September 2, 2023
• First Posted: September 11, 2023
• Study Start: October 1, 2023
• Primary Completion: October 1, 2024
• Study Completion: December 1, 2024
• Last Updated: September 14, 2023

Record last verified: 2023-09