Upper Extremity Functional Skills in Patients With Parkinson Disease (pwPD)

NCT07180004 | Completed

• 1 other identifier: Parkinson
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 2

Brief Summary

Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms such as bradykinesia, resting tremor, and/or rigidity.Patients with Parkinson's disease (pwPD) often exhibit poor manual dexterity and decreased strength. Fine motor deficits seen in PD include an inability to control cognitive power/force, poor manual dexterity, and motor dysfunction, which includes difficulties achieving the angles, speed, and coordination required for basic movements. Anatomical strength, as detailed in activities of daily living (ADL), is an important indicator of motor characteristics and vitality.Studies have shown a strong relationship between postural control and fine motor functions. For high-quality distal movement, better proximal stabilization is necessary. During upper extremity functions, the body's center of gravity must shift with arm movements, allowing adaptation to changing gravity. Good trunk control is essential in this dynamic process of maintaining balance. Studies examining this link between trunk control, balance, and hand functions are available in the literature. Among these studies conducted in diverse populations, studies involving PD are very few. Investigating parameters such as grip strength, upper extremity dexterity, and reaction time in PD will fill the gap in the literature. Meta-analysis studies have shown that muscle strength and strength in individuals with PD are lower than in healthy individuals. Furthermore, muscle strength in PD has been shown to be related to functional capacity and disease severity. In light of all this information, our study was designed to investigate the relationship between upper body muscle strength, particularly proximal and distal, and manual dexterity in PD. In this direction, the aim of this study is to determine the relationship between proximal and distal muscle strength and upper extremity functional abilities in PD.

Conditions

PARKINSON DISEASE (Disorder); Upper Extremity; Muscle Strength Development; Functional Skills

Outcome Measures

Primary Outcomes (3)

• Muscle Strength Measurement

  The isometric strength measurement will be performed using a digital muscle strength measurement device (KFORCE KINVENT) for the bilateral serratus anterior, upper trapezius, latissimus dorsi, deltoid, supraspinatus, teres minor, subscapularis, and biceps brachii muscles of the upper extremity.

  first day of assesment

• Grip Strength Measurement

  A Jamar hand dynamometer (Baseline®) and a PinchMeter (Baseline Mechanical Pinch Gauge with Case, Blue, 30 lb) will be used for grip strength measurement.The isometric strength measurement will be performed using a digital muscle strength measurement device (KFORCE KINVENT) for the bilateral serratus anterior, upper trapezius, latissimus dorsi, deltoid, supraspinatus, teres minor, subscapularis, and biceps brachii muscles of the upper extremity. Grip Strength Measurement: A Jamar hand dynamometer (Baseline®) and a PinchMeter (Baseline Mechanical Pinch Gauge with Case, Blue, 30 lb) will be used for grip strength measurement.

  first day of assesment

• The 9-Hole Peg Test (DDPT)

  The 9-Hole Peg Test (DDPT) is a validated test for PD that measures manual dexterity in seconds based on performance. The test material consists of nine standard-sized small rods and a nine-hole platform. The test will be administered with the patient in a seated position. The patient will be asked to place nine rods in the round compartment of the box as quickly as possible into the holes of the box, starting from the edge farthest from the compartment. Once completed, immediately remove them from the compartment, starting from the edge closest to the compartment. The test will begin with the dominant hand, and the time will be measured with a stopwatch. The time will begin when the hand touches the rods and will end when the last rod is placed in the box. The same procedure will be applied to the other hand. In this study, the arithmetic average of the test times, repeated twice, will be recorded separately for each hand.

  first day of assesment

Secondary Outcomes (4)

• Demographic Form

  first day of assesment

• Modified Hoehn & Yahr (m-HY) scale

  first day of assesment

• Unified Parkinson's Disease Rating Scale (UPDRS)

  first day of assesment

• Mini Mental State Examination (MMSE)

  first day of assesment

Study Arms (2)

1/study group

Individuals between the ages of 40 and 75 diagnosed with idiopathic Parkinson's disease (n=40)

2/control group

Healthy individuals between the ages of 40-75 (n=30)

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged between 40 and 75 years (n=40±5) who applied to the Neurology Clinic of the Faculty of Medicine of the University Hospital, diagnosed with Idiopathic Parkinson's disease by a neurologist, having stage ≤4 on the Modified Hoehn\&Yahr (m-HY) scale, and having scores of ≥22 in the educated and ≥18 in the uneducated according to the Mini Mental State Examination, and healthy individuals of a similar age group (n=30±5)

You may qualify if:

• Healthy individuals aged 40-75 years, diagnosed with idiopathic PD according to the UK Parkinson's Disease Association Brain Bank criteria by a specialist neurologist, with a Modified Hoehn \& Yahr (m-HY) scale stage ≤4, and with a Mini Mental State Examination score of ≥22 for those with training and ≥18 for those without training, and with no known disease, volunteered to participate in the study.
• Individuals with no other known neurological and/or systemic disease
• Individuals without any upper extremity contractures

You may not qualify if:

• Individuals with diagnosed and/or treated psychiatric illnesses who are considered unable to complete the tests.
• Those taking neuroleptic medications or antidepressants.
• Individuals with orthopedic conditions that interfere with manual dexterity tests, such as severe dyskinesia, carpal tunnel syndrome, tendon injuries, or finger amputations; rheumatological conditions such as rheumatoid arthritis and osteoarthritis; and individuals with any neurological condition other than PD.

Sponsors & Collaborators

• Kahramanmaras Sutcu Imam University: lead

Study Sites (2)

Kahramanmaraş Sütçü imam University

Kahramanmaraş, onikişubat, 46100, Turkey (Türkiye)

Location

Kahramanmaraş Sütçü İmam University

Kahramanmaraş, Onikişubat, 46100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• hatice adıgüzel tat, Associate Professor

  Kahramanmaras Sutcu Imam University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 4, 2025
• First Posted: September 18, 2025
• Study Start: January 1, 2025
• Primary Completion: December 15, 2025
• Study Completion: December 15, 2025
• Last Updated: December 24, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)