Chronic Effect of Isometric Exercise on Blood Pressure in Patients With Hypertension

NCT07147595 | Completed

• 1 other identifier: UP5965-21
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

International recommendations support dynamic or isometric strength training as an adjunct to aerobic exercise. Given the lack of consensus, this study aims to evaluate the chronic effects of isometric exercise, performed through handgrip or isometric knee extension, as a hypotensive strategy in adults with hypertension.

Conditions

Hypertension (HTN); Hypertension Arterial

Outcome Measures

Primary Outcomes (1)

• Bood pressure

  Bood pressure (systolic and diastolic) measured by Ambulatory Blood Pressure Monitoring

  Assessments (systolic/diastolic pressure) will be performed at baseline and after 4 weeks of training (post-intervention).

Study Arms (3)

Control

NO INTERVENTION

Isometric handgrip exercise

EXPERIMENTAL

Small Mass Muscle - isometric handgrip exercise

Procedure: Isometric handgrip exercise

Isometric knee extension exerice

EXPERIMENTAL

Large Mass Muscule - isometric knee extension exercise

Procedure: Isometric knee extension exercise

Interventions

Isometric handgrip exercise PROCEDURE

Participants will train 3 times per week for 4 weeks. Each session will consist of four sets of 2-minute contractions sustained at 30% of maximum voluntary contraction (MVC), performed with a handgrip device for each arm, with 1-minute rest intervals between sets and between arms.

Isometric handgrip exercise

Isometric knee extension exercise PROCEDURE

Participants will train 3 times per week for 4 weeks. Each session will consist of four sets of 2-minute contractions sustained at 30% of maximum voluntary contraction (MVC), performed with adjustable ankle weights for each leg, with 1-minute rest intervals between sets and between legs.

Isometric knee extension exerice

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with controlled hypertension under medication. Sedentary or physically inactive individuals.

You may not qualify if:

• Pregnant women. Unstable angina. Heart failure classified as NYHA class II, III, or IV. Recent cardiovascular event within the last 3 months. Chronic renal insufficiency. Diabetes mellitus. History of malignant disease with a life expectancy of less than 2 years. Orthopedic, physical, or mental limitations that prevent the performance of physical exercise.

Sponsors & Collaborators

• Instituto de Cardiologia do Rio Grande do Sul: lead

Study Sites (1)

Instituto de Cardiologia do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, 90620-001, Brazil

Location

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Alexandre Lehnen, PhD

  Instituto de Cardiologia do Rio Grande do Sul

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Study Record Dates

• First Submitted: August 14, 2025
• First Posted: August 29, 2025
• Study Start: August 31, 2023
• Primary Completion: September 1, 2023
• Study Completion: February 28, 2025
• Last Updated: August 29, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)