Combined Effects of Alternate Nostril Breathing and Aerobic Interval Training on Blood Pressure and Heart Rate Products in Patients With Hypertension

NCT07177989 | Recruiting

• 1 other identifier: FUI/CTR/2025/92
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertension (HTN) is the foremost preventable risk factor for cardiovascular disease (CVD) and all-cause mortality, contributing to over 7 million deaths annually within the nearly 17 million attributed to CVD. Effective management through lifestyle modifications, including aerobic exercises specifically interval training presents a promising avenue for blood pressure regulation by promoting vasodilation and regulating the autonomic nervous system. Likewise, alternate nostril breathing has demonstrated efficacy in lowering blood pressure by optimizing oxygenation and improving endothelial function but their combined effect on BP measures is yet to be determined. Hence this study aims to determine the combined effects of aerobic interval training with and without alternate nostril breathing on blood pressure, rate pressure product and quality of life in patients with hypertension.

Conditions

Hypertension (HTN)

Keywords

hypertension; intensity interval training; nostril breathing; heart rate; blood pressure

Outcome Measures

Primary Outcomes (3)

• heart rate

  heart rate will be measured by pulse oximeter

  05 weeks

• blood pressure

  it will be measured by pulse oximeter

  05 weeks

• Rate pressure product

  it will be evaluated by formula : systolic blood pressure x heart rate resting by using sphygmomanometer

  05 weeks

Study Arms (2)

Interventional group (Group B)

EXPERIMENTAL

Patients in this group will perform alternative nostril breathing along with aerobic interval training. A protocol of total 5 weeks. Three sessions per week on alternate days will be done under the supervision of physiotherapist. All outcome measurements would be performed first at baseline and terminal after the 5 weeks intervention period

Other: Experimental Group

Interventional group (Group A)

ACTIVE COMPARATOR

Patients in tis group will perform aerobic interval training. A protocol of total 5 weeks. Three sessions per week on alternate days will be done under the supervision of physiotherapist. All outcome measurements would be performed first at baseline and terminal after the 5 weeks intervention period

Other: interventional group A

Interventions

Experimental Group OTHER

The interventional group will perform aerobic training (stationary cycling) 3 days a week for 5 weeks, starting with 40-60% heart rate reserve (HRR) for 20-30 minutes, with thein the first week and increasing to 40-85% HRR, maintaining a target heart rate of 40-60% HRR at the lower end and 75-85% HRR at the upper end, following a 1:4 work-to-rest ratio for 30-40 minutes in subsequent weeks, with the warm up of 5 mins before the session and a cool down of 5-7 mins after every seasion. Exercise heart rate will be calculated using the Karvonen formula for the base line week and the following weeks.Following each aerobic session, they'll practice Alternate Nostril Breathing (ANB), beginning with 5 minutes in the first week and progressing to 10 minutes thereafter. ANB involves specific hand positioning and breathing techniques to promote relaxation and balance. All sessions will be supervised by a physiotherapist.

Interventional group (Group B)

interventional group A OTHER

In interventional group 'A' participants will perform aerobic training for 3 days a week for 30-40 minutes a day for 5 consecutive weeks. Exercise heart rate will be calculated using the Karvonen formula. For the first base line week the aerobic session begins with a 5-minute warm-up. The primary cardiovascular component involves using a cycle ergometer (stationary cycling) at an intensity of 40-60% heart rate reserve (HRR) for 20-30 minutes. Finally, the workout will concludes with a cool-down phase lasting 5-7 minutes, allowing the heart rate to gradually return to baseline and preventing post-exercise hypotension. From the second week onwards, the aerobic training session will begin with a 5-minute warm-up to prepare the body and gradually increase heart rate. The main workout involves a cycle ergometer, maintaining a target heart rate of 40-60% HRR at the lower end and 75-85% HRR at the upper end, following a 1:4 work-to-rest ratio for 30-40 minutes. The session ends with a 5-7 min

Interventional group (Group A)

Eligibility Criteria

• Age: 25 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 25- 50 years -males and females
• Patients diagnosed with stage 1 hypertension 130 - 139 / 80 - 89 mmHg and stage 2 hypertension, BP level ≥140/90 mmHg. according to AHA/ACC 2017 Guidelines-Individuals who are able to understand and follow the instructions for exercise

You may not qualify if:

• Diagnosed with any current infections
• subjects with diagnosed musculoskeletal or neurological conditions which hinder participation in physical activity program
• Active Smokers
• Those with any contraindication to exercise testing or training.
• Pregnant females

Sponsors & Collaborators

• Foundation University Islamabad: lead

Study Sites (1)

Foundation University College of Physical Therapy, Islamabad, 44000

Rawalpindi, 46000, Pakistan

RECRUITING

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Sameen Fatima, DPT

CONTACT

03335169660; sameenfatimaniazi@gmail.com

Zara Khalid, PhD

CONTACT

03335415822; zara.khalid@fui.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This is a randomized controlled trial having two groups. One group (Group B), will receive alternative nostril breathing along with aerobic interval training and the other group group B) will receive only aerobic interval training.

Study Record Dates

• First Submitted: September 10, 2025
• First Posted: September 17, 2025
• Study Start: January 15, 2025
• Primary Completion: January 15, 2026
• Study Completion: February 15, 2026
• Last Updated: September 17, 2025

Record last verified: 2025-09

Locations

PA (1)