Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients

NCT03982758 | Unknown

• 1 other identifier: PCaetano
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

International recommendations advocate dynamic or isometric strength training as an adjunct to aerobic exercise. Due to a lack of consensus, this research addresses the acute effects of isometric exercises by handgrip or lower limb isometry as a hypotensive strategy in hypertensive adults.

Conditions

Arterial Hypertension

Outcome Measures

Primary Outcomes (1)

• blood pressure

  Blood pressure will be evaluated by Ambulatory Blood Pressure Monitoring (ABPM) over 24h. For that, a Dyna-Map® branded instrument will be used, which will measure blood pressure on rest condition and another measure after the exercise session (totaling 48 horas), in all participants of the two study groups.

  48 hours

Study Arms (2)

isometric handgrip exercise

EXPERIMENTAL

Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.

Other: isometric handgrip exercise

isometric of lower limbs

EXPERIMENTAL

Isometric session for lower limbs: 4 series with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute.

Other: isometric of the lower limbs

Interventions

isometric handgrip exercise OTHER

Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.

isometric handgrip exercise

isometric of the lower limbs OTHER

Isometric session for lower limbs: 4 sets with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute rest.

isometric of lower limbs

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Controlled hypertensive patients (use of medication) sedentary or physically inactive

You may not qualify if:

• Pregnant women;
• Unstable angina;
• Class II, III or IV heart failure;
• Recent cardiovascular event (last 3 months);
• Chronic renal insufficiency;
• Diabetes;
• History of malignant diseases with life expectancy \<2 years;
• Or Orthopedic limitations or any physical or mental limitation that impedes the performance of physical exercises.

Sponsors & Collaborators

• Instituto de Cardiologia do Rio Grande do Sul: lead

Study Sites (1)

Instituto de Cardiologia/ fundação Universitária de Cardiologia

Porto Alegre, Rio Grande do Sul, 90040-371, Brazil

RECRUITING

Related Publications (1)

• Oliveira PC, Dipp T, Waclawovsky G, Lehnen AM. Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial. Clinics (Sao Paulo). 2025 Apr 16;80:100612. doi: 10.1016/j.clinsp.2025.100612. eCollection 2025.

  PMID: 40245790 DERIVED

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Patricia Caetano, graduate

  Instituto de Cardiologia/ Fundação Universitária de Cardiologia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Patrícia Caetano, graduate

CONTACT

+5551992039364; fisio.patriciacaetano@gmail.com

Alexandre Lehnen, PHD

CONTACT

+555199768092; amlehnen@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigador

Study Record Dates

• First Submitted: April 15, 2019
• First Posted: June 12, 2019
• Study Start: December 9, 2019
• Primary Completion: March 18, 2022
• Study Completion: March 18, 2022
• Last Updated: July 28, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)