NCT07140367|Recruiting
"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"
TAME-OA
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TAME-OA
Sponsor study identifier
observational
43
1 country
1
Study Start
September 1, 2025
Actual (reported)Primary Completion
September 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
September 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Patients with knee OA and chronic pain refractory to at least 3 months of conventional conservative therapy will be included in the study, which will evaluate the clinical results obtained after treatment with selective arterial embolization (selection and enrollment, treatment with selective arterial embolization, follow-up checks). Forty-three patients will be included in the study and will undergo the transarterial microembolization procedure after signing the informed consent form for participation in the study and the collection of anamnestic data. Subsequently, patients will be followed up with clinical evaluation at 1, 3, 6, 12, and 24 months of follow-up or until possible dropout for other treatment.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 18, 2025
Actual (reported)August 24, 2025
Actual (reported)September 1, 2025
Actual (reported)September 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
September 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Reduction of pain (VAS score)
Clinical assessment regarding pain by Visual Analogue Scale (VAS) score (0-100 mm), in which 0 represents no pain, and 100 represents maximum pain imaginable.
1 year
Improvement in quality of life (SF-36)
2 years
Pain, stiffness, and physical functioning of the joints (WOMAC score)
2 years
Identification of the hypervascularization of the knee. Selective and super-selective catheterization of pathological genicular arterial branches, through the use of micro-catheters. - Injection of embolizing material (Nexsphere-F - Kardia) - Control of technical success: the embolization will be followed by diagnostic arteriography that will evaluate the success of the procedure (occlusion of more than 90 percent of the pathologic vasculature).
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients affected by inflammatory arthropathy of the knee who underwent genicular artery microembolization.
IRCCS Istituto Ortopedico Rizzoli
Bologna, Bologna, 40136, Italy
Sapoval M, Querub C, Pereira H, Pellerin O, Boeken T, Di Gaeta A, Ahmar MA, Lefevre-Colau MM, Nguyen C, Daste C, Lacroix M, Laredo JD, Sabatier B, Martelli N, Chatellier G, Dean C, Rannou F. Genicular artery embolization for knee osteoarthritis: Results of the LipioJoint-1 trial. Diagn Interv Imaging. 2024 Apr;105(4):144-150. doi: 10.1016/j.diii.2023.12.003. Epub 2023 Dec 14.
Little MW, O'Grady A, Briggs J, Gibson M, Speirs A, Al-Rekabi A, Yoong P, Ariyanayagam T, Davies N, Tayton E, Tavares S, MacGill S, McLaren C, Harrison R. Genicular Artery embolisation in Patients with Osteoarthritis of the Knee (GENESIS) Using Permanent Microspheres: Long-Term Results. Cardiovasc Intervent Radiol. 2024 Dec;47(12):1750-1762. doi: 10.1007/s00270-024-03752-7. Epub 2024 May 31.
First Submitted
August 18, 2025
First Posted
August 24, 2025
Study Start
September 1, 2025
Actual (reported)Primary Completion
September 1, 2029
EstimatedPrecision Rehabilitation: Mechanisms and Efficacy of Vibration in Exercise Training for Degenerative Knee Osteoarthritis
Range of motion
2 years
Overall assessment of treatment
2 years
Bilateral Trans- and Suprapatellar Circumferences
2 years
Contact the study team to confirm eligibility.
Okuno Y, Korchi AM, Shinjo T, Kato S. Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol. 2015 Apr;38(2):336-43. doi: 10.1007/s00270-014-0944-8. Epub 2014 Jul 4.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
September 1, 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 7, 2026
Record last verified: 2026-04
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