Combined Effect of Low Level Laser Therapy and Neural Mobilization on Lumber Disc Prolapse

NCT07138300 | Completed DMC

• 1 other identifier: P.T.REC\012\004894
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study attempts to answer the following research question: what is the combined effect of low level laser therapy and neural mobilization on lumber disc prolapse in decreasing pain, improving functional disability, improving neural mobility and improve lumber flexion mobility?

Conditions

Low Level Laser Therapy

Outcome Measures

Primary Outcomes (5)

• pain assessment before and after treatment

  by visual analog scale (VAS)

  4 weeks

• Functional disability :evaluate the patient's ability to perform various activities of daily living

  by Oswestry Disability Index (ODI)

  4 weeks

• evaluate neural mobility before and after treatment

  by Straight leg raising test (SLR) ,The range of motion of the SLR test was measured as the angle of hip flexion in relation to the horizontal

  4weeks

• evaluate lumbar flexion mobility before and after treatment

  by Schober's test

  4weeks

• Neurological assessment screening of neuropathic pain

  by slump test

  4 weeks

Study Arms (2)

Experimental group (B)

EXPERIMENTAL

20 patients will receive low level laser therapy plus neural mobilization. * Mobilization will be through using slump sitting maneuver (Both techniques 1. The slider neurodynamic mobilization technique: The patient moves actively and conversely from a position of neck and trunk flexion, knee flexion, and ankle plantar flexion, to a position of neck and trunk extension, knee extension and ankle dorsiflexion. 2. The tension neurodynamic mobilization technique: The patient moves actively and conversely from a position of neck and trunk extension, knee flexion, and ankle plantar flexion, to a position of neck and trunk flexion, knee extension, and ankle dorsiflexion * Low level laser therapy : Twenty points were established for treatment, 12 over the lumbar spine, at the same Side of the radicular pain, from l2 to s1 vertebra, distance between these points is 2 cm. In the thigh, eight points were marked at equal distances from each other, four in the path of l5 root and four in the path of

Device: Low Level Laser Therapy by (Eme Physio, Lasermed 2200), GaAs laser, 1 cm2 beam area,7,000 Hz, 17 mW, 1 J/cm2, Pesaro, Italy); Procedure: neural mobilization

control group (A)

ACTIVE COMPARATOR

20 will receive placebo laser therapy plus neural mobilization. Mobilization will be through using slump sitting maneuver (Both techniques slider and tensioner. Placebo laser therapy: patients receive the same treatment on the same area as experimental group for the same period without turning on the device. all 20 will receive Placebo laser therapy: patients receive the same treatment on the same area as experimental group for the same period without turning on the device.

Procedure: neural mobilization; Other: placebo laser therapy

Interventions

Low Level Laser Therapy by (Eme Physio, Lasermed 2200), GaAs laser, 1 cm2 beam area,7,000 Hz, 17 mW, 1 J/cm2, Pesaro, Italy) DEVICE

(Eme Physio, Lasermed 2200), GaAs laser, 1 cm2 beam area,7,000 Hz, 17 mW, 1 J/cm2, Pesaro, Italy) . Patient lies in side lying on the non-affected side which is opposite to the side of radicular pain, hip and knee in flexion 90. Twenty points were established for treatment, 12 over the lumbar spine, at the same Side of the radicular pain, from l2 to s1 vertebra, distance between these points is 2 cm. In the thigh, eight points were marked at equal distances from each other, four in the path of l5 root and four in the path of s1 root from hip to knee. The leaser probe is held in 90 degree over the skin with complete skin contact

Experimental group (B)

neural mobilization PROCEDURE

Mobilization will be through using slump sitting maneuver (Both techniques slider and tensioner. •The slider neurodynamic mobilization technique: The patient moves actively and conversely from a position of neck and trunk flexion, knee flexion, and ankle plantar flexion, to a position of neck and trunk extension, knee extension and ankle dorsiflexion The tension neurodynamic mobilization technique: The patient moves actively and conversely from a position of neck and trunk extension, knee flexion, and ankle plantar flexion, to a position of neck and trunk flexion, knee extension, and ankle dorsiflexion

Experimental group (B); control group (A)

placebo laser therapy OTHER

patients receive the same treatment on the same area as experimental group for the same period without turning on the device.

control group (A)

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• patients referred from orthopedic surgeon with diagnosis of lumbar disc prolapse and radiculopathy (subacute \>3 weeks or chronic \> 3 months and lasting up to 12 months) .
• Participants had MRI examination, which confirmed the diagnosis of lumber disc prolapse in addition of radiological changes in the intervertebral discs of the spine and affection of peripheral nerve root.
• Aged between 30 and 50 years .

You may not qualify if:

• Patients who had undergone any surgical intervention in the spine. 2- Any other dysfunctions of the spine rather than lumber disc prolapse (fractures, tumors, spondylolisthesis, rheumatic diseases, and cauda equina syndrome).
• The patient is under any medical treatment. 4- Pregnancy, cardiovascular failure, pacemaker, metal implants, skin lesions in the treatment area.
• Neurological deficits such as myelopathy, lumber canal stenosis and Piriformis syndrome 6- Malignancy, systemic inflammatory disease, or infectious disease. 7- Acute lumber disc prolapse will be excluded.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Giza, Egypt

Location

MeSH Terms

Interventions

Lasers, Semiconductor

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Officials

• Nasr A Abdelkader, PHD

  Assistant professor, Department of physical therapy for musculoskeletal disorders and its surgeries

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: the patient and the research assistant are blind about the treatment group.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor , department of physical therapy for musculoskeletal disorders and its surgeries

Study Record Dates

• First Submitted: August 16, 2025
• First Posted: August 22, 2025
• Study Start: February 1, 2025
• Primary Completion: May 25, 2025
• Study Completion: June 3, 2025
• Last Updated: August 22, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)