Effect of Neural Mobilization in Upper Cross Syndrome

NCT07017738 | Completed

• 1 other identifier: P.T.REC/012/005577
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of Neural Mobilization in patients with Upper Cross Syndrome.

Conditions

Upper Cross Syndrome

Outcome Measures

Primary Outcomes (3)

• Forward head angle

  The forward head angle between the line connecting the tragus and C7 with the perpendicular line will be measured for all participants in both groups pre- and post-treatment, using the photogrammetric method.

  6 weeks

• Rounded shoulder angle

  The rounded shoulder angle between the line between the acromion process and C7 with the perpendicular line will be measured for all participants in both groups pre- and post-treatment, using the photogrammetric method.

  6 weeks

• Kyphosis angle

  For the kyphosis angle, the bone marker on the spinous process of C7 will be used as the starting point of the arch and the spinous process of T12 will be used as the endpoint of the arch. It will be measured for all participants in both groups pre- and post-treatment, using the photogrammetric method.

  6 weeks

Secondary Outcomes (1)

• Boston Questionnaire (Arabic version)

  6 weeks

Study Arms (2)

Neural mobilization + Corrective exercises

EXPERIMENTAL

They will receive neural mobilization in addition to corrective exercises for UCS, 3 times per week for 6 weeks.

Other: Corrective exercises; Other: Neural mobilization

Corrective exercises

ACTIVE COMPARATOR

They will receive corrective exercise for UCS, 3 times per week for 6 weeks.

Other: Corrective exercises

Interventions

Corrective exercises OTHER

The corrective exercise program will include various positions: in standing, scapular retraction and arms overhead; in sitting, chin tuck and thoracic extension; in supine, arms in a W shape and horizontal abduction with external rotation; in side-lying, forward flexion starting with arms parallel to the body; and in prone, scapular retraction and depression in a T shape, extension from 90° forward flexion, and horizontal abduction at 90° with external rotation. Exercises will start with three repetitions held for 10 seconds and progress to six repetitions held for 25 seconds, based on overload principles and individual needs. Participants experiencing pain may stop and rest until symptoms subside.

Corrective exercises; Neural mobilization + Corrective exercises

Neural mobilization OTHER

Median nerve mobilization will be performed with the patient in a supine position, shoulder abducted to 90°, elbow flexed at 90°, and both wrist and head in a neutral position. The therapist will mobilize the nerve by extending the elbow to 45°, while the patient performs ipsilateral cervical lateral flexion to unload the nervous system.

Neural mobilization + Corrective exercises

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age ranged from 20 to 50 years.
• Body Mass Index ≤30 kg/m².
• All participants have a forward head, craniovertebral angle \< 50°.
• All participants have round back (kyphosis angle ≥ 42°).
• All participants have rounded shoulders of ≥ 52°.
• The subjects were chosen from both genders based on an assessment of upper cross syndrome by photogrammetric analysis.
• All participants have pain intensity level measured by visual analogue scale (4-8).
• All participants tested positive for upper limb tension test of median nerve.

You may not qualify if:

• History of trauma or surgery in the cervical region.
• Bone fractures or acute soft tissue injuries.
• Osteoporosis.
• Pregnant women.
• Cancer.
• Neurological conditions affecting cervical and thoracic spine.
• Connective tissue disease: This includes diseases such as osteomyelitis, lupus, and scleroderma.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Giza, Egypt

Location

MeSH Terms

Conditions

Oculocerebral hypopigmentation syndrome type Preus

Study Officials

• Abeer Abdelrahman, PhD

  Professor, Cairo university

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 4, 2025
• First Posted: June 12, 2025
• Study Start: June 10, 2025
• Primary Completion: December 10, 2025
• Study Completion: December 15, 2025
• Last Updated: January 9, 2026

Record last verified: 2026-01

Locations

EG (1)