NCT07122934

Brief Summary

Posterior circulation strokes (PCS) represent \~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,828

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2003

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2003

Completed
20.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2023

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

August 8, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 8, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 14, 2025

Completed
Last Updated

August 14, 2025

Status Verified

August 1, 2025

Enrollment Period

20.2 years

First QC Date

August 8, 2025

Last Update Submit

August 8, 2025

Conditions

Acute Ischemic StrokePosterior Circulation Brain InfarctionArterial Occlusion Disease

Outcome Measures

Primary Outcomes (1)

  • Modified rankin scale at three months

    3 months

Study Arms (2)

Development and Internal validation cohort

Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

External validation cohort

Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

Interventions

Assessment of cervico-cerebral arterial occlusion patternDIAGNOSTIC_TEST

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

Development and Internal validation cohortExternal validation cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients suffering from an acute ischemic stroke (AIS) clinically and/or radiologically attributable to a posterior circulation arterial occlusion

You may qualify if:

  • age \>18 years old
  • admitted within 24h from last known well

You may not qualify if:

  • simultaneous clinical and/or radiological strokes in the posterior and anterior circulation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Ischemic StrokeBrain Infarction

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesBrain IschemiaInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior registrar

Study Record Dates

First Submitted

August 8, 2025

First Posted

August 14, 2025

Study Start

February 1, 2003

Primary Completion

March 31, 2023

Study Completion

August 8, 2025

Last Updated

August 14, 2025

Record last verified: 2025-08