Posterior Circulation ASTRAL Prognostic Score
Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation
1 other identifier
observational
2,000
2 countries
2
Brief Summary
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event. Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2003
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedFirst Submitted
Initial submission to the registry
June 6, 2023
CompletedFirst Posted
Study publicly available on registry
June 15, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
November 24, 2025
CompletedApril 8, 2025
April 1, 2025
19 years
June 6, 2023
April 3, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
3 months modified Ranking scale
evaluation of 3 months neurological disability
January 2003-December 2021
Study Arms (15)
ASTRAL
Basel cohort
Berlin cohort
Bern Cohort
Bologna cohort
Dijon cohort
Lisbon cohort
Israel cohort
Innsbruck cohort
St. Gallen cohort
Lugano cohort
Chicago cohort
West Virginia cohort
Zurich cohort
Seoul cohort
Interventions
ASTRAL prognostic score
Eligibility Criteria
The participants included in this study are exclusively patients with acute ischemic stroke of the posterior circulation arriving at the hospital within 24h since last proof of good health. These patients must have a modified Rankin Score \<3 prior the event and available data concerning: age, NIHSS, glucose levels at admission, mRS prior to event and 3 months after the event and acute phase imaging characteristics (CT and/or MRI) including large vessel occlusion, leukoaraiosis and ASPECTS score from the acute CT scan.
You may qualify if:
- Isolated posterior circulation strokes based on clinical or/and imaging evidence.
- Arriving within 24h at hospital since last proof of good health.
You may not qualify if:
- no available data for 3 months modified Rankin Score
- modified Rankin Score≥3 prior the event
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Thessalylead
- University of Lausannecollaborator
- Centre Hospitalier Universitaire Vaudoiscollaborator
Study Sites (2)
First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki
Thessaloniki, Central Macedonia, 54636, Greece
Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne
Lausanne, Vaud Canton, 1011, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Internal Medicine George Ntaios
Study Record Dates
First Submitted
June 6, 2023
First Posted
June 15, 2023
Study Start
January 1, 2003
Primary Completion
December 31, 2021
Study Completion
November 24, 2025
Last Updated
April 8, 2025
Record last verified: 2025-04