NCT05906420|Active Not Recruiting
Posterior Circulation ASTRAL Prognostic Score
Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation
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Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation
Sponsor study identifier
observational
2,000
2 countries
2
Study Start
January 1, 2003
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Study Completion
November 24, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event. Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 24, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2003
Actual (reported)December 31, 2021
Actual (reported)June 6, 2023
Actual (reported)June 15, 2023
Actual (reported)November 24, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
3 months modified Ranking scale
evaluation of 3 months neurological disability
January 2003-December 2021
ASTRAL prognostic score
The participants included in this study are exclusively patients with acute ischemic stroke of the posterior circulation arriving at the hospital within 24h since last proof of good health. These patients must have a modified Rankin Score \<3 prior the event and available data concerning: age, NIHSS, glucose levels at admission, mRS prior to event and 3 months after the event and acute phase imaging characteristics (CT and/or MRI) including large vessel occlusion, leukoaraiosis and ASPECTS score from the acute CT scan.
First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki
Thessaloniki, Central Macedonia, 54636, Greece
Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne
Lausanne, Vaud Canton, 1011, Switzerland
First Submitted
June 6, 2023
First Posted
June 15, 2023
Study Start
January 1, 2003
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Tenecteplase in Wake-up Ischaemic Stroke Trial
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Study Completion
November 24, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 8, 2025
Record last verified: 2025-04
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