Menopausal Impact on Skin Aging Among Egyptian Women

NCT07120542 | Not Yet Recruiting

• 1 other identifier: Soh-Med--25-7-1MS
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to understand how menopause affects skin aging in Egyptian women between the ages of 40 and 60. The main question the study wants to answer is: Does menopause cause any changes in how the skin ages? To find out, the participants will be divided into two groups based on their menstrual history:

• Women who have not yet gone through menopause (premenopausal)
• Women who have already gone through menopause (postmenopausal) A researcher will examine the skin of women in both groups to look for signs of aging. Then, the results will be compared to see if there are any differences between the two groups.

Conditions

Skin Aging

Outcome Measures

Primary Outcomes (2)

• Clinical skin aging severity using Glogau Photoaging Scale

  The Glogau Photoaging Scale will be used for evaluation. Facial assessment will be conducted both at rest and during facial animation to observe dynamic changes. Participant will be categorized into 4 types or grades where type 1 is mild skin aging and type 4 is severe skin aging

  Assessed once at baseline during participant's visit

• Dermoscopic skin aging score using the dermoscopic photoaging assessment scale

  this scale is used to assess facial skin aging. The face will be divided into four regions: the forehead, right cheek, left cheek, and chin. Each region will be examined for the presence of the following features: yellowish discoloration, yellow papules, white linear areas indicating skin atrophy, lentigines, hypo- or hyperpigmented macules, telangiectasia, actinic keratoses, senile comedones, deep wrinkles, superficial wrinkles, and criss-cross wrinkles. Scoring follows a binary (yes/no) approach, where the presence of a given feature in any of the four regions scores one point, yielding a total possible score ranging from 0 to 44. a higher score means worse outcome.

  Assessed once at baseline during participant 's visit

Secondary Outcomes (3)

• Prevalence of specific clinical and dermoscopic aging features

  Recorded during clinical and dermoscopic assessment at baseline

• Correlation between menopausal status and severity of skin aging

  Assessed once at baseline during participant's visit based on menopausal history and skin aging scores

• Correlation between menopausal duration and skin aging

  Menopausal duration collected via history at baseline; skin aging assessed at baseline

Interventions

Dermoscopy DEVICE

dermoscopic assessment of skin aging signs

Eligibility Criteria

• Age: 40 Years - 60 Years
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This study will include Egyptian women between the ages of 40 and 60 years who are either premenopausal or postmenopausal, based on their menstrual history. participants must be in good general health and not currently receiving hormone replacement therapy or any treatment known to affect skin condition.

You may qualify if:

• Females aged 40 to 60 years
• Egyptian nationality or residency
• Ability to provide informed consent
• Classified as either:
• Premenopausal (still menstruating regularly)
• Postmenopausal (no menstruation for ≥12 months)

You may not qualify if:

• Menopausal transition (Perimenopausal women
• Menopause induced by hysterectomy
• History of hormone therapy in the past 6 months
• Active dermatological conditions affecting the face (e.g. eczema, psoriasis)
• Use of anti-aging skin treatments (e.g. laser, fillers, retinoids)
• Severe chronic illnesses that may affect skin condition

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Interventions

Dermoscopy

Intervention Hierarchy (Ancestors)

Intravital Microscopy; Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: July 23, 2025
• First Posted: August 13, 2025
• Study Start: November 1, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2027
• Last Updated: August 13, 2025

Record last verified: 2025-08