A 56-Day Exploratory Study of NatureU® Mind Care BeautyU Caps on Skin Aging Parameters

NCT07571629 | Completed

• 1 other identifier: A225000034310100101C
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

This was a 56-day, single-center, open-label, single-arm exploratory study evaluating within-participant changes in skin-aging parameters after daily oral intake of NatureU® Mind Care BeautyU Caps in adult women. Participants took one capsule daily for 56 days. The primary outcome was change from baseline in crow's-feet wrinkle count at Day 56 assessed by PRIMOS CR imaging. The secondary outcome was change from baseline in stratum corneum hydration at Day 56 assessed by Corneometer CM 825. Additional exploratory outcomes included other wrinkle topography parameters, skin elasticity, radiance, pigmentation, pore-related parameters, dermal thickness and density, and participant-reported skin appearance outcomes.

Conditions

Skin Aging

Keywords

NatureU; oral beauty supplement; skin hydration; PQQ; quercetin; ergothioneine; proanthocyanidins.

Outcome Measures

Primary Outcomes (1)

• Change From Baseline in Crow's-Feet Wrinkle Count at Day 56

  Crow's-feet wrinkle count was assessed using PRIMOS CR imaging. The primary endpoint was the within-participant change from baseline to Day 56.

  Baseline and Day 56

Secondary Outcomes (1)

• Change From Baseline in Stratum Corneum Hydration at Day 56

  Baseline and Day 56

Other Outcomes (1)

• Change From Baseline in Additional Wrinkle Topography Parameters at Day 28 and Day 56

  Day 28, Day 56

Study Arms (1)

NatureU® Mind Care BeautyU Caps

EXPERIMENTAL

Participants received NatureU® Mind Care BeautyU Caps, one capsule orally once daily for 56 days.

Dietary Supplement: NatureU® Mind Care BeautyU Caps

Interventions

NatureU® Mind Care BeautyU Caps DIETARY_SUPPLEMENT

An oral nutricosmetic supplement containing PQQ, quercetin, ergothioneine, cranberry polyphenols, and related formulation components. Participants took one capsule daily for 56 days.

NatureU® Mind Care BeautyU Caps

Eligibility Criteria

• Age: 36 Years - 56 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adult woman aged 36 to 56 years, inclusive.
• Healthy participant as judged by the investigator.
• Cheek skin hydration below 60 C.U.
• Visible crow's-feet wrinkles.
• Facial laxity or reduced facial radiance.
• At least one visible facial spot meeting the prespecified size and ITA value criteria.
• Willing to take the study product once daily for 56 consecutive days.
• Willing to complete scheduled skin assessments at baseline, Day 28, and Day 56.
• Willing to maintain regular lifestyle habits during the study period.
• Willing to avoid confounding skincare products, cosmetic procedures, medications, and health products during the study period.
• Provided written informed consent before any study-related procedure.

You may not qualify if:

• Skin condition that could interfere with study assessments.
• Highly allergic constitution.
• Known allergy or intolerance to any ingredient of the study product.
• Pregnant or lactating.
• Planned pregnancy during the study period.
• Severe systemic illness.
• Serious psychiatric disorder.
• Serious endocrine disorder.
• Recent participation in another clinical study.
• Recent use of products or procedures that could influence skin outcomes.
• Use of other oral or topical products that could interfere with skin-aging assessments during the study period.
• Recent cosmetic dermatology procedures or treatments that could affect the target assessment areas.
• Inability to comply with study procedures.
• Any condition judged by the investigator to make participation inappropriate.

Sponsors & Collaborators

• OmniSolutions Laboratory Holdings Limited: lead

Study Sites (1)

CTI AiPu Medical Laboratory (Shanghai) Co., Ltd

Shanghai, Shanghai Municipality, 200040, China

Location

Study Officials

• Luke Law, Dr

  OmniSolutions Laboratory Holdings Limited

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 6, 2026
• Study Start: January 11, 2025
• Primary Completion: March 8, 2025
• Study Completion: March 8, 2025
• Last Updated: May 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)