Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women

NCT06083402 | Completed

• 1 other identifier: HyaCera2023
• Study Type: interventional
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. In this double-blind, randomized, placebo-controlled trial, the investigators will recruit healthy men and women with mild to moderate signs of skin aging and randomly assign them to either receive a HyaCera™ or placebo for 12 weeks. The investigators will perform a series of objective and subjective measurements to assess changes in skin condition. The investigators hypothesize that consumption of HyaCera™ leads to improvements in the general condition of the skin including skin hydration, crow's feet wrinkling, and other skin aging parameters.

Conditions

Skin Aging

Keywords

skin aging; skin wrinkles; skin hydration; skin elasticity; skin firmness; skin smoothness; crow's feet wrinkles; dietary supplement; skin barrier function

Outcome Measures

Primary Outcomes (3)

• Crow's Feet Wrinkles

  Degree of crow's feet wrinkling will be measured via Visioscan®

  at week 0, Week 4, Week 8, and Week 12

• Skin Smoothness

  Skin smoothness will be measured via Visioscan®

  at week 0, Week 4, Week 8, and Week 12

• Skin Hydration

  Skin surface hydration will be measured via Corneometer® 825

  at week 0, Week 4, Week 8, and Week 12

Secondary Outcomes (3)

• Skin Elasticity

  at week 0, Week 4, Week 8, and Week 12

• Skin Barrier Function

  at week 0, Week 4, Week 8, and Week 12

• Skin Scaliness

  at week 0, Week 4, Week 8, and Week 12

Other Outcomes (2)

• Dermatologist grading of skin condition

  at week 0, Week 4, Week 8, and Week 12

• Self-evaluation of perceived changes in skin condition

  at week 0, Week 4, Week 8, and Week 12

Study Arms (2)

Active

ACTIVE COMPARATOR

Participants receive 1 HyaCera™ capsule orally once daily for 12 weeks

Dietary Supplement: HyaCera™

Placebo

PLACEBO COMPARATOR

Participants receive 1 placebo capsule orally once daily for 12 weeks

Dietary Supplement: Placebo

Interventions

HyaCera™ DIETARY_SUPPLEMENT

1 Ritual HyaCera capsule once daily

Active

Placebo DIETARY_SUPPLEMENT

1 placebo capsule once daily

Placebo

Eligibility Criteria

• Age: 25 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy male and female volunteers, 25 - 70 years old with mild to moderate fine lines and wrinkles
• All ethnicities and skin types
• Willing to maintain current skincare regimen on face, arms, and legs and withhold all facial and body treatments throughout the course of the study

You may not qualify if:

• Self-reported pregnant or breastfeeding or planning to become pregnant during the course of the study
• Any conditions on the face, arms and legs that would interfere with evaluations
• Under treatment for any known health issues/medical conditions including chronic health conditions and skin diseases/conditions

Sponsors & Collaborators

• Natals, Inc. dba Ritual: lead

Study Sites (1)

Princeton Consumer Research

Raritan, New Jersey, 08869, United States

Location

Related Publications (1)

• Grier-Welch AM, Vance AY, Alamdari N, Sharafi M. Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial. Dermatol Ther (Heidelb). 2025 Dec;15(12):3689-3702. doi: 10.1007/s13555-025-01556-2. Epub 2025 Oct 10.

  PMID: 41071523 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Neither the participants nor the investigators will know the group assignment. Supplements will be prepared by the sponsor and marked with unidentifiable ID numbers before being sent to study site.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Healthy men and women with mild to moderate signs of skin aging will be randomly assigned to either receive a Ritual HyaCera or placebo for 12 weeks

Study Record Dates

• First Submitted: August 16, 2023
• First Posted: October 16, 2023
• Study Start: June 12, 2023
• Primary Completion: October 6, 2023
• Study Completion: October 6, 2023
• Last Updated: October 16, 2023

Record last verified: 2023-10

Locations

US (1)